DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATL3 and atl3

DIOPT Version :9

Sequence 1:	NP_056274.3	Gene:	ATL3 / 25923	HGNCID:	24526	Length:	541	Species:	Homo sapiens
Sequence 2:	NP_001006016.1	Gene:	atl3 / 449995	ZFINID:	ZDB-GENE-041010-109	Length:	513	Species:	Danio rerio

Alignment Length:	502	Identity:	352/502 - (70%)
Similarity:	412/502 - (82%)	Gaps:	4/502 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    22 SKPGPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYS 86
            |:|||||:|.|.|::|||:||.:||:.|||...:||..||||||||||||||||:|||:|||:|
Zfish     3 SEPGPVQIVTVNKEKHSFDLDTEALSRILLVPEVRDKHVVVVSVAGAFRKGKSFLLDFLLRYMY- 66

Human    87 QKESGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVAVVLMDTQGAFDSQS 151
             ::.| .:|||...:|||||||||||:|||||||:|||||.|.|..|.:|||:||||||||||||
Zfish    67 -RKPG-QDWLGQDNDPLTGFSWRGGSEPETTGIQLWSEVFVVRKKDGSEVAVLLMDTQGAFDSQS 129

Human   152 TVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLVRDWS 216
            ||||||||||||||||||||||||||||||||||||||||||||||||.|.||||:|||||||||
Zfish   130 TVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEFFLKPFQSLMFLVRDWS 194

Human   217 FPYEYSYGLQGGMAFLDKRLQVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGK 281
            |||||.||.:||.:|||||||||:.||||:|.||.||||||:.::|.|||||||:|||||.|.|:
Zfish   195 FPYEYKYGFKGGSSFLDKRLQVKQSQHEELQTVREHIHSCFTSISCLLLPHPGLKVATSPAFTGQ 259

Human   282 LKDIAGEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQA 346
            |.|:|.||||.|:.|||.:|....|..|||||:|||||||||||||||||||||.||||||||:|
Zfish   260 LCDVAPEFKEGLRELIPNLLKTDDLAVKEINGNKVTCRGLLEYFKAYIKIYQGEGLPHPKSMLEA 324

Human   347 TAEANNLAAAASAKDIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKKMGGKDFSF 411
            |||||||||.|||||.||.|||:||||:.||::|:.|||||..|.|.||..|..||||||:.|..
Zfish   325 TAEANNLAAVASAKDQYYKNMEKVCGGDLPYVAPNSLEEKHRFFLQEALHLFSSTKKMGGQHFCH 389

Human   412 RYQQELEEEIKELYENFCKHNGSKNVFSTFRTPAVLFTGIVALYIASGLTGFIGLEVVAQLFNCM 476
            |||::||:|:||::||..|||.||||||.||||||||..:..||:.||:..|||||.|:...:|:
Zfish   390 RYQEQLEKELKEMWENLSKHNESKNVFSAFRTPAVLFVLVCLLYVLSGILFFIGLETVSFACDCI 454

Human   477 VGLLLIALLTWGYIRYSGQYRELGGAIDFGAAYVLEQASSHIGNSTQ 523
            |||.:||:|||.:|||||.|||:|.|||.....:||||:. :.|.|:
Zfish   455 VGLAMIAILTWAFIRYSGHYREVGTAIDQATGVILEQATD-VLNKTR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATL3	NP_056274.3	P-loop_NTPase	37..305	CDD:304359	200/267 (75%)
atl3	NP_001006016.1	P-loop_NTPase	17..279	CDD:304359	199/264 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338470
Domainoid	1	1.000	410	1.000	Domainoid score	I4405
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9149
Inparanoid	1	1.050	710	1.000	Inparanoid score	I4187
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		oto48861
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300