DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATL3 and atl

DIOPT Version :9

Sequence 1:	NP_056274.3	Gene:	ATL3 / 25923	HGNCID:	24526	Length:	541	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	276/531 - (51%)
Similarity:	376/531 - (70%)	Gaps:	19/531 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    25 GPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKE 89
            |....|:...::|:|.|:|.||:.:|::|.::|..|.||||||||||||||:|||.|||:|| |.
  Fly     3 GSAVQVINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYS-KY 66

Human    90 SGH--SNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVAVVLMDTQGAFDSQST 152
            ..|  ::|||...:||.||||||||:.:||||.:||::|..:.|.|.|:|::|:|||||||||||
  Fly    67 VHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQST 131

Human   153 VKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLVRDWSF 217
            |:||||:||||||.||||||||||||||||||.|||||||||||:.:..:||||.|.||||||||
  Fly   132 VRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSF 196

Human   218 PYEYSYGLQGGMAFLDKRLQVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKL 282
            |||..||..||...|.:||:|.:.||.|:|::|.||.|||::|.|||:|||||.|||:|.|||:|
  Fly   197 PYEAEYGALGGDKILKRRLEVSDKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRL 261

Human   283 KDIAGEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQAT 347
            :||..|||..|::|:|.:|.|..|:.|||:|.:|..|.|::||::|:.||:|.:||.|||||.||
  Fly   262 QDITPEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVAT 326

Human   348 AEANNLAAAASAKDIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKKMGGKDFSFR 412
            ||||:|.|.|:||::|...|||||||.:||||...|:.:|...|..||..|...:||||::|:.:
  Fly   327 AEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEK 391

Human   413 YQQELEEEIKELYENFCKHNGSKNVFSTFRTPAVLFTGIVALYIASGLTGFIGLEVVAQLFNCMV 477
            ::::||::::|::.|:..||.|||:|...|||||.|...|.:||.||:.|.:||...|...|.::
  Fly   392 FRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVM 456

Human   478 GLLLIALLTWGYIRYSGQYRELGGAIDFGAAYV------------LEQASSHIGNSTQATVRDAV 530
            |:.|:.|..|.||||||:..:.||.:|..|..:            :|:...|:  :|.||  :..
  Fly   457 GVALLTLALWAYIRYSGELSDFGGKLDDFATLLWEKFMRPIYHGCMEKGIHHV--ATHAT--EMA 517

Human   531 VGRPSMDKKAQ 541
            ||..:...::|
  Fly   518 VGGGAASYRSQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATL3	NP_056274.3	P-loop_NTPase	37..305	CDD:304359	171/269 (64%)
atl	NP_001287506.1	GBP	14..289	CDD:280433	172/275 (63%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	73/154 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I803
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	627	1.000	Inparanoid score	I862
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		otm42142
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870