DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC5 and CG5196

DIOPT Version :9

Sequence 1:	NP_056272.2	Gene:	ZDHHC5 / 25921	HGNCID:	18472	Length:	715	Species:	Homo sapiens
Sequence 2:	NP_650191.1	Gene:	CG5196 / 41522	FlyBaseID:	FBgn0038039	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	242	Identity:	69/242 - (28%)
Similarity:	115/242 - (47%)	Gaps:	45/242 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     2 PAESG-KRFKPSKYVPVSAAAIF-LVGATTLFFAFTCPGLSLYVSP----AVPIYNAI-MFLFVL 59
            |..|| :||  ..:.|::|.:|. .:..|||:..      |::..|    |...:.|: :.|..|
  Fly     3 PEISGFRRF--LHWGPITALSIIKCITLTTLYMN------SMWWPPNKSFAGFAHQALFLLLSTL 59

Human    60 A--NFSMATFMDPGIFPRAEEDEDKED-DFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCS 121
            |  |:.|||...||:.|:....:|.:| .|                :::|..|..|:.||..||.
  Fly    60 ATFNYVMATLTGPGLMPKQWHPKDPKDAQF----------------LQYCKKCEGYKAPRSHHCR 108

Human   122 VCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLL-SLTAHIMGV------FGFGL---LYVLYHIE 176
            .||.||::.||||||:|:|:|..|:.||..||| |:...:.|.      |..|:   .|:.:.:.
  Fly   109 KCDRCVKKMDHHCPWINHCVGWANHAYFTYFLLFSILGSLQGTVVLCCSFWRGIYRYYYLTHGLA 173

Human   177 ELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTG 223
            .|:.|:..:...:||:.|: .:.:..:.|..::|..:.:|.....||
  Fly   174 HLASVQFTLLSIIMCILGM-GLAIGVVIGLSMLLFIQLKTIVNNQTG 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:366691	41/135 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..715
		DUF4671	594..>704	CDD:374041
CG5196	NP_650191.1	zf-DHHC	89..223	CDD:279823	42/148 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810