Protein Alignment ZDHHC5 and app

DIOPT Version :10

• Sequence 1: NP_056272.2
• Gene: ZDHHC5 / 25921
• HGNCID: 18472
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 193/729 - (26%)
• Similarity: 274/729 - (37%)
• Gaps: 221/729 - (30%)

Human    22 IFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDE----DK 82
            |.:.|.:.|||||.||.|:..::||:||..|:::.|.:::....||.|||:.|||..||    :|
  Fly    51 ILITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEK 115

Human    83 E----DDFRAPLY------KTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWV 137
            :    :...:|.|      |.|.:||..|::|:|.||:.:||||.||||:|||||:.||||||||
  Fly   116 QIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWV 180

Human   138 NNCIGRRNYRYFFLFLLSLTAHIMGVFGFG-----LLYVLYHIEELSGVRTAVTMAVMCVAGLFF 197
            .||:|:||||:|:|||:||.  .:.||.|.     |:.::....|:..|..|....|:.|...||
  Fly   181 GNCVGKRNYRFFYLFLVSLA--FLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFF 243

Human   198 I--PVAGLTGFHVVLVARGRTTNEQVTGKF--RGG---VNPFTNG-CCNNVSRVLCSSPAPRYLG 254
            .  .|.||.|||..|....:||||.:.|.|  :||   .||::.| .|.|...:||
  Fly   244 SIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILC--------- 299

Human   255 RPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPD 319
                                 |.:|..::|       ||
  Fly   300 ---------------------GPMTPSLID-------RR-------------------------- 310

Human   320 LSRYTGLRTHLGLATNEDSSLLAKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEP 384
                       |:||:|                          ....|.|.||.:.:..|.|
  Fly   311 -----------GIATDE--------------------------FIQQMQHQSSPRHALSDVL--- 335

Human   385 TSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQ---SI 446
                 |:.|....|:                    |:..|.....:..| |.|..:|..:   ..
  Fly   336 -----SASHMVTTSQ--------------------PMMGGLGGGGIGGA-GGGISIGGAELKPRF 374

Human   447 RSEGTTSTS--------YKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTS--PF 501
            ..|...|:|        .....|...||   :|     ...|.::.||.|..........|  ..
  Fly   375 YDESNPSSSTLEGNGGAINGHGNGHGNG---FD-----HPPPSYDLVQNGKSRKHHQQRCSLQTL 431

Human   502 LSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVAS-LQEREKLLRQSPPLPGREEEPG 565
            |.|...||.:|.:|                ::..|.:|:||: ||:.|......|..|.....|.
  Fly   432 LPASAQQQFKASKH----------------KHKQLKQHLVAAELQQHEGGPGPGPNSPSLLRSPA 480

Human   566 LGDSGIQSTPGSGHAPRTSSSSDDSKRSPL----------GKTPLGRPAVPRFGKPDGLRGRGVG 620
            ...|...:...|.|.|.| .|.||.:.|||          ..|.:|..|........|..|...|
  Fly   481 TSSSYRLNLKRSLHLPLT-PSYDDVRHSPLPLLHHHVHAQQTTAIGTVAAAAAAVASGASGTNTG 544

Human   621 SPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKD---EVQLKTTYSKSNGQPKSLGS 682
                  |....|.|.|.::..|...||.:...|..||...:.   ::|.....|.||....::.:
  Fly   545 ------TGTGTGGSSSSATTTAPTSVSVSLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHT 603

Human   683 ASPGPGQPPLSSPT 696
            .:|   |.|  :||
  Fly   604 TAP---QAP--APT 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:396215	61/131 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..715		85/435 (20%)
app	NP_648561.2	DHHC	146..270	CDD:396215	60/125 (48%)