DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZDHHC5 and Zdhhc8

DIOPT Version :9

Sequence 1:	NP_056272.2	Gene:	ZDHHC5 / 25921	HGNCID:	18472	Length:	715	Species:	Homo sapiens
Sequence 2:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	242/769 - (31%)
Similarity:	335/769 - (43%)	Gaps:	206/769 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    12 SKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVS--PAVPIYNAIMFLFVLANFSMATFMDPGIFP 74
            ::|:|.:.|.|.|:..|.|||.:.|   ..||.  |.|..|..::..||||||::||||||||.|
  Fly     8 TRYIPATFAWIVLLLTTFLFFFYPC---QFYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIP 69

Human    75 RAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNN 139
            :|..|||.|::.||||||..||.||.|:||||.||:|||||||||||||::|:|.||||||||||
  Fly    70 KASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNN 134

Human   140 CIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLT 204
            ||||||||:||.||:||:.|::.:|...|:|||..:..:......|.:.:|.:..:..||:.|||
  Fly   135 CIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTILAIPIFGLT 199

Human   205 GFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSP-APRY--LGRPKKEKTIVIRP 266
            |||:|||:|||||||||||||:||.|||:.||.:|    .|.:. .|:|  |..|||..:
  Fly   200 GFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHN----CCYTQFGPQYPSLLNPKKYAS----- 255

Human   267 PFLRPEVSDGQITVKIMD--------------NG---IQGELRRTKSKGSLEITESQSADAEPPP 314
              .|.:|.:..|:....|              ||   :.|......|.|.:..|..|.:     |
  Fly   256 --RRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQYS-----P 313

Human   315 PPKPDLSRY---TGLRTHL--GLATNEDSSLLAKDSPPTPTMY-KYRPGYSSSSTSAAMPHSSSA 373
            ....|.||.   ..::|::  |...|:.|.        :.|:| |..||...|.|....|.:|.:
  Fly   314 RSFYDASREKRGIQVKTYMAEGNGYNQRSG--------STTLYSKLSPGRECSDTDLEPPPASQS 370

Human   374 KLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLS-SGSRSSSLKSAQGTG 437
            :    |.  |||...:  ||.|                  .||:...:| ||..:.|:.:..|.|
  Fly   371 Q----DC--EPTPPLQ--RHNS------------------SSFYLPQVSDSGGLNGSVSTGGGGG 409

Human   438 FELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEP-DPPLGYTSPF 501
                                       ..|..:..|..|..||     .|.|.. ||..||||..
  Fly   410 ---------------------------GDSPRHMRLYHPRHSP-----HARPRGLDPQRGYTSDA 442

Human   502 LSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGL 566
            ||                   |.|    ||.|   ...:..|.|::::.|..:
  Fly   443 LS-------------------PDH----PVGY---GVGVNGSQQQQQQALAAA------------ 469

Human   567 GDSGIQSTPGSGHAPRTSSSSDDSKRSPLG-KTPL-----------GRPAVPRFGKPD--GLRGR 617
            ..:...:......|..|::.:...:..||| .|||           |.|..||  :||  ||..:
  Fly   470 AAAAAVAAQNQRSATTTATPTMQQRIKPLGVATPLVMASPVRRSNPGTPTQPR--RPDFIGLNAQ 532

Human   618 GV-----------------------GSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVAL----- 654
            .|                       |.|...|.||.:       .|:.|..:.:.:.|.:
  Fly   533 AVAQQQQQQQQAAAAAAAAYYEYTSGLPPQHPQAPSI-------QQQQQQLLLQQQRVLMQHQQQ 590

Human   655 QPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGG 708
            |..|..:.:.|.:.....::.|..:|..|:.| |.|.....:.|.:.: .|.||
  Fly   591 QQALQQQQQQQQQAAVHAAHPQHAALAQAAYG-GSPQRRFLSEGELVR-QGAGG 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:366691	76/124 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..715		98/470 (21%)
		DUF4671	594..>704	CDD:374041	33/151 (22%)
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	76/124 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3570
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		otm41899
orthoMCL	1	0.900	-	-		OOG6_104772
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	1	1.000	-	-		X1910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.900