DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IFFO1 and LamC

DIOPT Version :9

Sequence 1:	XP_011519249.1	Gene:	IFFO1 / 25900	HGNCID:	24970	Length:	651	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	465	Identity:	85/465 - (18%)
Similarity:	162/465 - (34%)	Gaps:	173/465 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   232 DTI---TPEIRALY-NVLAKVKRERDE-----------YKRRWEEEYTVRIQL------------ 269
            ||:   |..::|:| ..||..::..||           .||.|||...::.:|
  Fly    83 DTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAEN 147

Human   270 -----QDRVNELQEEAQEADACQ-------EELALKVEQLKAEL-VVFKGLMSNNLSELDTKIQE 321
                 ::|.||:..:..::.|.:       :||||:.|:|:.:| .:.|.|.:..|:.:|.:.|.
  Fly   148 NARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQN 212

Human   322 KAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQKKLVPSMGGRKRERKAAVEEDTSLSESEG 386
            ::::.::....::. |.:|.:...:|..|                              :||.:|
  Fly   213 QSLREELAFKDQVH-TQELTETRSRRQIE------------------------------ISEIDG 246

Human   387 --PRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAE 449
              .||.:.            ::|:.|.:||     |..:.......||..||:::......|||.
  Fly   247 RLSRQYEA------------KLQQSLQELR-----DQYEGQMRINREEIELLYDNEIQNLKAAAN 294

Human   450 --AQGEVTSAPGLRALWLCLSSLKPTPPLLSLLCPPMWLSSSTCVSPLPLSFCFSFSSFFNQTSS 512
              |||...:...:|.:...:..|...
  Fly   295 RAAQGSALATEEVRLMRTKIDGLNAK--------------------------------------- 320

Human   513 LSLSLTWPFGMRPIPSLLGWPPPLPFLLQQQEDS---LEKVIKDTESLFKTREKEYQETIDQIEL 574
                                       ||..||:   |...|::.|:|..|..:.:.:.|..:|.
  Fly   321 ---------------------------LQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEA 358

Human   575 ELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAED 639
            ||...:::|...|.||..:..:|..||:::....:|:  .|:.:     .:.:..|..|     .
  Fly   359 ELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLL--CGEER-----RLNIESPGRP-----T 411

Human   640 SDRDVSSDSS 649
            :|..:||:.|
  Fly   412 TDSGISSNGS 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IFFO1	XP_011519249.1	Filament	230..>360	CDD:278467	35/167 (21%)
IFFO1	XP_011519249.1	Filament	<540..610	CDD:278467	20/72 (28%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	79/438 (18%)
		ATP-synt_B	<67..>142	CDD:304375	15/58 (26%)
		MreC	<178..>224	CDD:302802	12/45 (27%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000