Protein Alignment GALNT2 and Pgant1

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 222/591 - (37%)
• Similarity: 306/591 - (51%)
• Gaps: 49/591 - (8%)

Human     9 LCFAFLWVLGIAYYMYSGGGS----------ALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEE 63
            |||       |.|......||          ..|...|.|..|.|.:::.:....:....|..|:
  Fly    20 LCF-------ILYSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPYEQ 77

Human    64 KAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQR 128
            ..|.  .|...||...:.....::.|.....|.:.|.:...|:..|::|..:|::.|.|:..|.:
  Fly    78 IIQL--DLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVGDHRNPLCAK 140

Human   129 KQWRVD-LPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLG---- 188
            :::..| ||..||||.|.||..|.|||||.|.|.......:||||||||.|::.|.||.|.
  Fly   141 QRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVR 205

Human   189 -KIE--KVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVS 250
             :|.  ||.:||...|.||:|:|:.||..|...||.|||:|||.|..|.||||:|:.|.||.|:.
  Fly   206 TRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLV 270

Human   251 PIIDVINMDNFQYV--GASADLKGGFDWNLVFKWDYMTPEQRRSR------QGNPVAPIKTPMIA 307
            ||||||:.::|||.  |..:...|||.||..|.|..: ||:.:.|      |...:.|..:|.:|
  Fly   271 PIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINL-PEREKQRQRRECKQEREICPAYSPTMA 334

Human   308 GGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGG 372
            ||||.:|:.||.|:|.||..||.|||||||:|||:|||||::|.||||||||:||..|||.||..
  Fly   335 GGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPND 399

Human   373 SGTVFARNTRRAAEVWMDEYKNFYYAAVPSAR-NVPYGNIQSRLELRKKLSCKPFKWYLENVYPE 436
            ..| ...||.|.|.||||||.|.::...|..: :...|::..|:.|||||.||.|:|||:|:|||
  Fly   400 RDT-HGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPE 463

Human   437 LRVPDHQDIAFGALQ--QGTNCLDTL--GHFADGVVGVYECHNA-GGNQEWALTKEKSVKHMDLC 496
            ..||......:|.:.  ....|||.|  .:......|:|.|... ..:|.::.|....:::...|
  Fly   464 KFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNELSC 528

Human   497 LTVV-DRAPGSLIKLQGCRENDS-RQKWEQIEGNSKLRHVGSNLCLDSRTAKS-GGLSVEVCGP- 557
            .||. ..:|...:.:..|.|||. .::|..  .:..:.|..:.:|||.:..|| ....|..|.|
  Fly   529 ATVQHSESPPYRVVMVPCMENDEFNEQWRY--EHQHIIHSNTGMCLDHQGLKSLDDAQVAPCDPH 591

Human   558 ALSQQW 563
            :.||:|
  Fly   592 SESQRW 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		4/20 (20%)
		Catalytic subdomain A	135..240		57/111 (51%)
		pp-GalNAc-T	139..434	CDD:133004	155/310 (50%)
		Catalytic subdomain B	300..362		40/61 (66%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	31/127 (24%)
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	155/310 (50%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	31/132 (23%)