Protein Alignment GALNT2 and Pgant3

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 226/647 - (34%)
• Similarity: 311/647 - (48%)
• Gaps: 124/647 - (19%)

Human     9 LCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPP 73
            |...:|::|..|::|::...:.......||                         .|:.....||
  Fly    11 LWLLYLFLLFFAFFMFAISINLYVASIQGG-------------------------DAEMRHPKPP 50

Human    74 GKVR--WPDFNQEA-YVG-----GTMVR-------------SGQD-------PYAR--------- 101
            .|.|  ||..|..| |:|     |.|..             .|.|       |..|
  Fly    51 PKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRL 115

Human   102 NKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPH 166
            |.||.:.||::.::|.:.|.|..:|:.|::...||:|||:|.|||||.|.||||:.||:.:||.|
  Fly   116 NSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRH 180

Human   167 LIKEIILVDDYSNDPEDGALLGKIEKV-----RVLRNDRREGLMRSRVRGADAAQAKVLTFLDSH 226
            |:||||||||.|:.......|....||     |:.|..:|.||:.:|:.||:.|:..||||||:|
  Fly   181 LLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAH 245

Human   227 CECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRR 291
            |||:..||||||.|:.|.|..|:.|:||:|:.|||.|.....:..|.|:|.|.|:|  .:.:::|
  Fly   246 CECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRW--FSSDRKR 308

Human   292 SRQGN----PVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEII 352
            ...||    ...||.||.:|||||.:|:.||.|:|.||..|.||||||:|:|||:|||||.:||.
  Fly   309 QTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEIS 373

Human   353 PCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNF--YYAAVPSARNVPYGNIQSRL 415
            |||.||||||...|||||||...|...|..|||.||||:::.|  .|.:..:.......|:..|:
  Fly   374 PCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERV 438

Human   416 ELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGA---LQQGTNCLDTLGHFADGVVGVYECH--N 475
            .||::|.||||.|||||::||...| ..|..||.   |...|.|..           .|..|  |
  Fly   439 ALRERLQCKPFSWYLENIWPEHFFP-APDRFFGKIIWLDGETECAQ-----------AYSKHMKN 491

Human   476 AGG---NQEWALTKE----KSVKHM-------DLCLTV----VDRAPGSLIKLQGCRENDSRQKW 522
            ..|   ::||....|    |:.:.|       |.||..    |.|:..|.:.:..|..:......
  Fly   492 LPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDM 556

Human   523 EQIEGNSKLRHVGSNLC-------------LDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ 571
            ..|....::. ...|:|             |.:|.|.:..:.:..|....||.|.:.::.||
  Fly   557 FVITPKGQIM-TNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQ 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		2/20 (10%)
		Catalytic subdomain A	135..240		59/109 (54%)
		pp-GalNAc-T	139..434	CDD:133004	152/305 (50%)
		Catalytic subdomain B	300..362		41/61 (67%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	31/154 (20%)
Pgant3	NP_610256.1	pp-GalNAc-T	153..457	CDD:133004	152/305 (50%)
		beta-trefoil_Ricin_Pgant3-like	515..661	CDD:467338	20/104 (19%)