Protein Alignment GALNT2 and CG31776

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_722909.2
• Gene: CG31776 / 33568
• FlyBaseID: FBgn0051776
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 176/553 - (31%)
• Similarity: 272/553 - (49%)
• Gaps: 74/553 - (13%)

Human    53 KKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRA 117
            |:|.:.....|:.:::: ||..|:...||              ||.||.      .||::.::|:
  Fly   105 KEDSNRRGLGEQGRAVQ-LPNAKLNPDDF--------------QDFYAE------LSDRIPLNRS 148

Human   118 IPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPE 182
            :||||...|:::::..:||..:|:|.||:|..|.|||::.|::.:||..|:|:|:||||.||.||
  Fly   149 LPDTRPISCRKRKYLENLPNVTVIIAFHDEHLSVLLRSITSIINRSPVELLKQIVLVDDDSNLPE 213

Human   183 DGALLGKI------EKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERV 241
            .|..|.:|      :.:.:||...|.|.:::|:.....:..:||.|||||.|.|.:||.||||.:
  Fly   214 LGQQLEEIVAQNFPKIIHILRLPERRGSIKARMEAIRVSSCQVLVFLDSHIEVNTNWLPPLLEPI 278

Human   242 AEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMI 306
            ..:...|..||:|.|:...|.|...:...:.||:|.|..:...:.||.:....    .|.:||::
  Fly   279 VINPHIVTRPILDAISRKTFAYAKQNTMTRSGFNWWLESESLPIFPEDKSPDS----TPYRTPVL 339

Human   307 AGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPG 371
            :|.: .:|:.||..||.:|..:|.|..|..||||:||.|||.:..:||:||||:.::........
  Fly   340 SGAM-AIDRNYFLNLGGFDEQLDTWEAEKFEISFKVWMCGGMMLYVPCARVGHIGKRPMKSISSP 403

Human   372 GSGTVFARNTRRAAEVWMDEYKNFYYAAVPSA-RNVPYGNIQSRLELRKKLSCKPFKWYLENVYP 435
            |.....|||.:|.||||||.||.:.|...|.. :....|.:..|...|..|.||.|.||:..|.|
  Fly   404 GYHNFLARNYKRVAEVWMDNYKKYVYDKNPKLYKMANAGLLFQRKTKRNALECKTFDWYMTKVAP 468

Human   436 E-------LRVPDHQDIAFGALQQGTN----CLDTLG--HFADGVVGVYECHNA--GGNQEWALT 485
            :       |..|    :.|..:.:...    |:|:|.  |....|:.....||:  |.:|.|:||
  Fly   469 DFLKRYLALDSP----LVFSGVIESVAFPGFCVDSLNCRHTKPVVLARCTGHNSMPGEHQNWSLT 529

Human   486 KEKSVK---HMDLCLTVVDRAPGSLIK---LQGCRENDSRQKWEQIEGNSKLRHVGSN----LCL 540
            ::..::   ..|.||    .|.|...|   |..|.:|...|.|..   |.:.|.:...    .||
  Fly   530 QDHEIQLTNSKDDCL----EAQGLRSKSVWLFRCHKNGGNQYWYY---NHRHRWIQQGQIWVWCL 587

Human   541 DSRTA---KSGG-LSVEVCGP-ALSQQWKFTLN 568
            :::.|   |.|. |:.::|.. .|.||||...|
  Fly   588 EAQLASGHKVGKVLANKICDKNQLEQQWKVGRN 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		5/20 (25%)
		Catalytic subdomain A	135..240		47/110 (43%)
		pp-GalNAc-T	139..434	CDD:133004	111/301 (37%)
		Catalytic subdomain B	300..362		28/61 (46%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	37/141 (26%)
CG31776	NP_722909.2	pp-GalNAc-T	170..467	CDD:133004	111/301 (37%)
		beta-trefoil_Ricin_Pgant8-like	482..618	CDD:467339	38/142 (27%)