Protein Alignment GALNT2 and Pgant2

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_608773.2
• Gene: Pgant2 / 33556
• FlyBaseID: FBgn0031530
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 352/641 - (54%)
• Similarity: 435/641 - (67%)
• Gaps: 88/641 - (13%)

Human     1 MRRRSRMLLCFAFLWVLGIAYYMYS---------------------------------------- 25
            |||..::::..:.:|:..:.||..|
  Fly     1 MRRNIKLIVFVSIIWMFVMVYYFQSSTEKVENRALRLREVATAMQQYQDDSSSAAAASTARQWAP 65

Human    26 -GGGS---ALAGGAGGGA----------GRKEDW--NEIDPIKKKDLHHSNG----EEKAQSME- 69
             |||:   |.||.||.||          |..:|:  |.:..:|      .||    ||.:|.:.
  Fly    66 AGGGAGPGAAAGAAGSGADDPGGNVILIGSVKDFERNAVHGLK------LNGIVALEETSQGLSG 124

Human    70 -TLPPG------------KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDT 121
             |..||            :|.:  ||:..|:....:|:|:|||.||:|||..||.|..:|.||||
  Fly   125 GTGGPGGRLPVAPSGRGTEVEY--FNEAGYIRAGALRNGEDPYIRNRFNQEASDALPSNRDIPDT 187

Human   122 RHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGAL 186
            |:..|:.|::|.|||.|||:|||||||||.||||:||||.:||.|||:||:||||||:.||||..
  Fly   188 RNPMCRTKKYREDLPETSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLE 252

Human   187 LGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSP 251
            |.||:||||:|||:||||:||||:|||||.:.||||||||.||||.|||||||||.||.||||.|
  Fly   253 LAKIDKVRVIRNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCP 317

Human   252 IIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKF 316
            :||||:||||||:||||||:|||||||:|||:|::|.:|..|..:|...|:||||||||||:||.
  Fly   318 VIDVISMDNFQYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKA 382

Human   317 YFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNT 381
            ||.:||||||.||||||||||||||||||||||||||||||||||||:||||||||||.||||||
  Fly   383 YFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNT 447

Human   382 RRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIA 446
            |||||||||:||..||.|||.|:|:|:|||..||.|::||.|||||||||||||:|:.||.|::
  Fly   448 RRAAEVWMDDYKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQAPDPQEV- 511

Human   447 FGALQQ-GTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKL 510
             |..:| .|.||||:||..||.||::.|||.|||||||.||...:||.|||||:|..|.||.:.|
  Fly   512 -GQFRQDSTECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFARGSQVVL 575

Human   511 QGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPAL-SQQWKF 565
            :.|.:::: |:|...|| ..:||...|:|||||.....|:|.:.|..|| :|:|.|
  Fly   576 KACDDSEN-QRWIMREG-GLVRHYKINVCLDSRDQSQQGVSAQHCNSALGTQRWSF 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		6/26 (23%)
		Catalytic subdomain A	135..240		80/104 (77%)
		pp-GalNAc-T	139..434	CDD:133004	228/294 (78%)
		Catalytic subdomain B	300..362		54/61 (89%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	57/120 (48%)
Pgant2	NP_608773.2	pp-GalNAc-T	205..500	CDD:133004	228/294 (78%)
		beta-trefoil_Ricin_GALNT2	510..629	CDD:467312	57/122 (47%)