Protein Alignment GALNT2 and Pgant7

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_573301.2
• Gene: Pgant7 / 32836
• FlyBaseID: FBgn0030930
• Length: 591
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 210/609 - (34%)
• Similarity: 309/609 - (50%)
• Gaps: 80/609 - (13%)

Human     3 RRSRMLLCFAFLWVLGIAY---------------YMYSGGGSALAGGAGGGAGRK-----EDWNE 47
            |..|:.||  .|.:|.:.|               |....||...|.....|..|:     :....
  Fly    10 RICRLALC--LLVLLPLLYLLANWSDHHKRVQEAYHTRFGGPKFAHQRLEGRPREVPKLVDGLGN 72

Human    48 IDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKL 112
            .:|   ||:...:|..:.....:|.|.|....|.::..|                ..|...||::
  Fly    73 FEP---KDVKPRSGPGENGEAHSLSPDKKHMSDASEMEY----------------GMNIACSDEI 118

Human   113 RMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDY 177
            .|.|::.|||.::|:...:..|||.|||:|.||||..|.|:|||.||:.:||.|::.|||||||:
  Fly   119 SMHRSVRDTRLEECRHWDYPFDLPRTSVIIVFHNEGFSVLMRTVHSVIDRSPTHMLHEIILVDDF 183

Human   178 SNDPEDGALLGKIEK--------VRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWL 234
            | |.|:  |..::::        |:|:||..||||:|:|.|||..|..:|:.|||:|||.|.:||
  Fly   184 S-DKEN--LRSQLDEYVLQFKGLVKVIRNKEREGLIRTRSRGAMEATGEVIVFLDAHCEVNTNWL 245

Human   235 EPLLERVAEDRTRVVSPIIDVINMDNFQY---VGASADLKGGFDWNLVFKWDYMTPEQRRSRQGN 296
            .|||..:..|||.:..||||.|:..||:|   .|.....:|.|:|.:::| :...|.:.:.|:.:
  Fly   246 PPLLAPIYRDRTVMTVPIIDGIDHKNFEYRPVYGTDNHFRGIFEWGMLYK-ENEVPRREQRRRAH 309

Human   297 PVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVF 361
            ...|.::|..|||||.:::.||.|||.||..:.||||||.|:||::||||||:|.:||||||||:
  Fly   310 NSEPYRSPTHAGGLFAINREYFLELGAYDPGLLVWGGENFELSFKIWQCGGSIEWVPCSRVGHVY 374

Human   362 RKQHPYTF----PGGSGTVFARNTRRAAEVWMDE-YKNFYYAAVPSARNVPYGNIQSRLELRKKL 421
            |...||.|    ....|.:...|.:|..|.|.|: :|.::|...|.||.:..|:|..:|.|:|:|
  Fly   375 RGFMPYNFGKLASKKKGPLITINYKRVIETWFDDTHKEYFYTREPLARYLDMGDISEQLALKKRL 439

Human   422 SCKPFKWYLENV-------YPELRVPDHQDIAFGALQQ--GTNCLDTLGHFADGVVGVYECHNAG 477
            :||.|:|:::::       :|.|....|    :|.|:.  ...|||::||....::|:..||..|
  Fly   440 NCKSFQWFMDHIAYDVYDKFPGLPANLH----WGELRSVASDGCLDSMGHQPPAIMGLTYCHGGG 500

Human   478 GNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDS 542
            .||...|.....:...:.|:. .||..   |||..||.......|:..|....|.|.....|:..
  Fly   501 NNQLVRLNAAGQLGVGERCVE-ADRQG---IKLAVCRLGTVDGPWQYNEHTKHLMHRVHKKCMAL 561

Human   543 RTAKSGGLSVEVCGPALS-QQWKF 565
            ..| :..||:..|....| |||.|
  Fly   562 HPA-TQQLSLGHCDVNDSYQQWWF 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		4/20 (20%)
		Catalytic subdomain A	135..240		58/112 (52%)
		pp-GalNAc-T	139..434	CDD:133004	136/317 (43%)
		Catalytic subdomain B	300..362		38/61 (62%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	35/121 (29%)
Pgant7	NP_573301.2	pp-GalNAc-T	145..452	CDD:133004	136/310 (44%)
		beta-trefoil_Ricin_GALNT7	464..586	CDD:467315	37/130 (28%)