Protein Alignment GALNT2 and Pgant4

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 181/570 - (31%)
• Similarity: 288/570 - (50%)
• Gaps: 63/570 - (11%)

Human    43 EDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSG------------ 95
            :|.|.:..|.:.|        |.|... ||..|....|::..|.:.....|||
  Fly    75 QDRNSVVDIPRSD--------KLQGFR-LPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIEN 130

Human    96 -------QDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALL 153
                   ::.|..|.||.:.||::.::|::||.|.:.|:.:::...||..||:..|.||..:.||
  Fly   131 PDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLL 195

Human   154 RTVVSVLKKSPPHLIKEIILVDDYS-----NDPEDGALLGKI-EKVRVLRNDRREGLMRSRVRGA 212
            |::.||:.::||.|:|:|:||||.|     ..|.|..:.... ..|.::||..|:||:.:|:.||
  Fly   196 RSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGA 260

Human   213 DAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASAD-LKGGFDW 276
            ..|..:|:.|.|||.|.|.:||.||:|.:|.:......|::|.|:.::|.|...:.| .:|||||
  Fly   261 KVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDW 325

Human   277 NLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFR 341
            .:::|...:.||....:.    .|.::|::.||||.::..:|.:||.||..:|:||||..|:||:
  Fly   326 KMLYKQLPVLPEDALDKS----MPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFK 386

Human   342 VWQCGGSLEIIPCSRVGHVFR-KQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSA-R 404
            :|.|||.|..:|||||.|:|| ...|...|.|...| |:|.:|.|||||||||.:.|...|.. .
  Fly   387 IWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFV-AKNHKRVAEVWMDEYKQYVYKRDPKTYD 450

Human   405 NVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVP----DHQDIAFGALQQGTN---CLDTLGH 462
            |:..|::..:..:|::|.||.|.|::..|.|:..|.    :....|.|.:|...|   |||.:|.
  Fly   451 NLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGK 515

Human   463 FADGVVGVYEC----HNAGGNQEWALT--KEKSVKHMD-LCLTVVDRAPGSLIKLQGCRENDSRQ 520
            ..:..||::.|    .:...||.|.|:  ::..:|..| :||.|.:..|.:.:.:..|......|
  Fly   516 STEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQ 580

Human   521 KWEQIEGNSKLRHVGSN-LCLDSRTAKSGGLSVEVCGPALS----QQWKF 565
            .|.......:|.|..:| .||:...  ..|::..|.....:    |:|:|
  Fly   581 FWYYDRQTQRLVHGENNKRCLEGFV--ENGIAKVVANSCENGNDRQRWEF 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		5/20 (25%)
		Catalytic subdomain A	135..240		45/110 (41%)
		pp-GalNAc-T	139..434	CDD:133004	117/303 (39%)
		Catalytic subdomain B	300..362		30/61 (49%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	33/133 (25%)
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	117/303 (39%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	34/138 (25%)