Protein Alignment GALNT2 and Pgant9

DIOPT Version :10

• Sequence 1: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_725602.1
• Gene: Pgant9 / 246627
• FlyBaseID: FBgn0050463
• Length: 650
• Species: Drosophila melanogaster
• Alignment Length: 650
• Identity: 257/650 - (39%)
• Similarity: 343/650 - (52%)
• Gaps: 103/650 - (15%)

Human     2 RRRSR---MLLCFAF-LWVLGIAYYMY---------------SGGGSA--LAGGAG--------- 36
            ||||.   .|:.||. :|.. ||:.:|               ||.|||  :.||||
  Fly     6 RRRSTTIVKLVAFALAIWFC-IAFLVYTDDTRRRAAQEGAGASGAGSAPGVGGGAGGLGDPIALA 69

Human    37 -----------------GGAGRKEDWNEID--PI---KKKDLHHSNGEEKAQSMETLPP----GK 75
                             ||.|:|:..:|.|  |.   .|.||......:||.......|    .|
  Fly    70 LRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQPKKKPQEDSKK 134

Human    76 VRWPDFNQEAYVG-------------GTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQ 127
            |..|..|.|...|             ..|.::..|.:.:|.|||..||.:.:.|.:||.|...|:
  Fly   135 VIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCK 199

Human   128 -RKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDP------EDGA 185
             ..::..:||.|.|:|.|||||.:.|||||.|||.:||.|||.:||||||||:.|      ||
  Fly   200 DEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLED-- 262

Human   186 LLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVS 250
            ......||:::|..:||||:|:|:.||:.|::.|||:|||||||.|.||||||:|:|.:.|.||.
  Fly   263 YFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVC 327

Human   251 PIIDVINMDNFQY-----VGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGL 310
            |:||||:.:..:|     .|.:.   |||||||.|.| :..||:.|.|..:...|:.:|.:||||
  Fly   328 PVIDVISDETLEYHYRDSGGVNV---GGFDWNLQFSW-HPVPERERKRHNSTAEPVYSPTMAGGL 388

Human   311 FVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGT 375
            |.:|:.:|:.||.||...|:|||||||:||:.|.|||:|||:|||.|||:|||:.||.:..|. .
  Fly   389 FSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGV-N 452

Human   376 VFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVP 440
            |..:|:.|.||||||||..:||..:.:.:. .:|::..|.:||..|.||.|||||:|:||||.:|
  Fly   453 VLKKNSVRLAEVWMDEYSQYYYHRIGNDKG-DWGDVSDRRKLRNDLKCKSFKWYLDNIYPELFIP 516

Human   441 DHQDIAFGALQQ----GTNCLDTLG--HFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTV 499
            . ..:|.|.::.    |..|||...  ......||.|.||..||||.|.|:|...::..|.||
  Fly   517 G-DSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYWMLSKAGEIRRDDSCL-- 578

Human   500 VDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALS-QQW 563
             |.| |..:.|.||......|.|...|...:|.|..|..||....:|. .|.:|.|..:|| |||
  Fly   579 -DYA-GKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLAISESKD-KLLMEECSASLSRQQW 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		6/24 (25%)
		Catalytic subdomain A	135..240		63/110 (57%)
		pp-GalNAc-T	139..434	CDD:133004	153/305 (50%)
		Catalytic subdomain B	300..362		36/61 (59%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	43/124 (35%)
Pgant9	NP_725602.1	tolA	<91..>134	CDD:236545	10/42 (24%)
		pp-GalNAc-T	213..510	CDD:133004	153/304 (50%)
		beta-trefoil_Ricin_Pgant9-like	518..643	CDD:467340	43/127 (34%)