DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PLEKHG4 and trio

DIOPT Version :9

Sequence 1:	NP_001123199.1	Gene:	PLEKHG4 / 25894	HGNCID:	24501	Length:	1191	Species:	Homo sapiens
Sequence 2:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster

Alignment Length:	1185	Identity:	249/1185 - (21%)
Similarity:	411/1185 - (34%)	Gaps:	360/1185 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   267 LSQLQEAAPGAVYQV-----LLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYC 326
            |::..||.|..:|.|     |.|||...:......:|:.                    ..:.|.
  Fly   629 LARSGEADPNEIYSVARELELQVGSFAERVEQRRRRLDM--------------------AVIFYT 673

Human   327 HQ----AWLDFRRR----------------LEALLQN------------CQAACALLQGAIESVK 359
            |:    ||:|..|.                :|.:||.            |....:..:..::.::
  Fly   674 HEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR 738

Human   360 AVPQPMEPGEVGQLLQQTEVLMQQ--VLDSPW------------LAWLQCQGGRELT-----WLK 405
            ::......|.:..|....|.|.:|  .|:..|            |.:.: :..|.|:     | .
  Fly   739 SLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFE-RDARLLSVQMEMW-S 801

Human   406 QEVPEVTLSPDYRTAMDKADEL-------YDRVDGLLHQLTLQSNQRIQALE---LVQTLEARES 460
            :|:....||.||:    ||::|       ...:....:::..|....:|..|   .:...:|..:
  Fly   802 EELQHADLSRDYQ----KAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHT 862

Human   461 GLHQIEVWL-----QQVGWPALEEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGE-----KFLQP 515
            ...:||..|     :::....:.||....|:..:|. ..||.........:|.||     .|:.|
  Fly   863 AQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQL-CQFQNDANQVISWIRNGEAMLVASFVTP 926

Human   516 LTGWEAAELDPPGARF-------------LALRA------------QLTEFSRALAQRCQRLAD- 554
            .:..||.:|.....:|             :..||            .:.|.|..:.::.|:|..
  Fly   927 NSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTY 991

Human   555 AERLFQLFREALTW---AEEGQRVLAELEQE---------------RPGVVLQQLQLHWTRHPDL 601
            ||...:|...::.:   ||:...||..||:|               :...::|.:    ::|.:.
  Fly   992 AEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLI----SKHQEQ 1052

Human   602 PPAHFRKMWALATGLGSEAIR-----QECRWAWARCQ------------------DTWL----AL 639
            ..| |.|...||.......::     |:|......|:                  |.|.    :|
  Fly  1053 KEA-FLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSL 1116

Human   640 DQ-----KLEASLK--LPPVGSTASLCVSQ------------VPAAPAHPPLRKAYSFDR----- 680
            ||     ..|.|.|  :..:.:|....:|.            ......|...|......|
  Fly  1117 DQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKL 1181

Human   681 --NLGQSLSEPACHCHHA------ATI------------AACRRPEAGGGALPQASPTVPPPGS- 724
              .|..||.|.. |.|.:      |::            :.|.:.|...| :.|....:...|:
  Fly  1182 LIQLADSLVEKG-HAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLG-MSQQQLLLGSDGNS 1244

Human   725 ----------SDP---------------------RSLNRLQLVLAEMVATEREYVRALEYTMENY 758
                      |||                     :|..|.:.::||::.|||.||..|...::.:
  Fly  1245 SISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCF 1309

Human   759 FPELDR-PDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYA 822
            ..|... ..||..|.||...:|||::::..||...||||||.....|..|.:.|:....:|.||.
  Fly  1310 LEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYV 1374

Human   823 LYSKNKPRSDALMSSYGHTFFKDKQQALG-DHLDLASYLLKPIQRMGKYALLLQELARACGGPTQ 886
            .|.||||.|:.|:..:|.:||::.|:.|. || .|.:||:||:||:.||.|||::|...|   .:
  Fly  1375 HYCKNKPTSNNLLVQHGGSFFEELQRRLEVDH-PLPAYLIKPVQRITKYQLLLKDLLSCC---EE 1435

Human   887 ELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVR 944
            ....::|...::....:..||.:.:..::.|||::.:.|::|.||.|       ::|.||.   |
  Fly  1436 SHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE---R 1497

Human   945 RIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARD--TFVL 1007
            |:||||..|||:| ....:.|..:.:|......|:|:||.......:|.:|..|.....  ..||
  Fly  1498 RVFLFELYLLFAK-EVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVL 1561

Human  1008 QASSLAIKQAWTADI------------------------------SHLLWRQAVHNKEVRMAEMV 1042
            :|:||..||.|...:                              |..|..|...|...| ..:.
  Fly  1562 KATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDR-CSLA 1625

Human  1043 SMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSL-------- 1099
            |.|.||     ...|:..:.::...:|:.                 |.:....||.|
  Fly  1626 SFGSGN-----TTDSDNKLGNQEATWVVA-----------------DYIATSGSNELSVSKGQQV 1668

Human  1100 -------PGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSE 1157
                   .|:|..|.|  .||              |.:.....:..|...:.|...|......|.
  Fly  1669 EIVEPPTAGEPDFCLV--RLN--------------PQHDDAAVQEGLVPVSVLKPPPGSHKHGSG 1717

Human  1158 ISSQCPSASGSSGSD 1172
            .::...|::||..||
  Fly  1718 TAANAASSAGSQKSD 1732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHG4	NP_001123199.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..152
		SPEC	447..>598	CDD:321951	38/207 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..728		6/52 (12%)
		RhoGEF	736..906	CDD:306973	60/171 (35%)
		PH_puratrophin-1	899..1034	CDD:270062	43/173 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1176		6/23 (26%)
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103	28/168 (17%)
		SPEC	782..997	CDD:238103	42/221 (19%)
		SPEC	897..1119	CDD:238103	42/227 (19%)
		SPEC	1125..1226	CDD:197544	16/101 (16%)
		RhoGEF	1287..1456	CDD:279015	60/172 (35%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	38/125 (30%)
		PH	1495..1580	CDD:278594	28/88 (32%)
		SH3_Kalirin_1	1643..1707	CDD:212786	14/96 (15%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810