Protein Alignment PAMR1 and modSP

DIOPT Version :10

• Sequence 1: NP_056245.2
• Gene: PAMR1 / 25891
• HGNCID: 24554
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_536776.2
• Gene: modSP / 42032
• FlyBaseID: FBgn0051217
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 166/806 - (20%)
• Similarity: 254/806 - (31%)
• Gaps: 264/806 - (32%)

Human     1 MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCREC-CEYDQIECVCPGKR---EV 61
            |:|..:....|.|..|||      ::..|..||..:::......| .:||    ||.|::   :.
  Fly     1 MQLISFLSNPLFFCALLL------KFRTIFAACDSSQFECDNGSCISQYD----VCNGEKNCPDG 55

Human    62 VGYTIPCCRNEENEC---------DSCLI-HPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAEC 116
            ...|...|.::...|         .:|:| ..||   .....|.:||               .|.
  Fly    56 SDETALTCVSQRQHCTKPYFQCTYGACVIGTAGC---NGVNECADGS---------------DET 102

Human   117 RAGWYGGDCMRCGQVLRAPKGQILLESYPLNAHC-EWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
            |        :|||.     :..|......|..:| |.......|..:.        :.:::|
  Fly   103 R--------LRCGN-----EDDIRQHDRRLQGNCKENEFKCPSGICLD--------KSNFLC--- 143

Human   181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCF 245
                   |.:|.      |                    :||: .||      |.:..|....|
  Fly   144 -------DGKDD------C--------------------ADGT-GFD------ESVELCGHMEC- 167

Human   246 HDGTCVLDKAGSYKC---ACLAG----------YTGQRCENLLEAGKSKIKASEDSLSVLEERNC 297
                    .|.|:||   .|::|          |.|.....||.....|:.....:.:.||...|
  Fly   168 --------PAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGC 224

Human   298 SDPGG---PVNGYQKITG-GPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ-P 357
            ..|.|   |:     :|| |..::.|...: || |.|.|...|||.|.|...|.:| :||... |
  Fly   225 PLPLGDERPI-----LTGDGSRVLTGPITR-GT-VRFSCKQGYVLEGEESSYCAKN-KWSTSTIP 281

Human   358 ICIKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKL-----QSAPTKKPALPFGDLP 417
            .|:|.|......|                        .:|.:.|     |....:||..|.|
  Fly   282 KCVKYCSTAGEFD------------------------GYSTKALCTHNGQQVECRKPFHPPG--- 319

Human   418 MGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQG------ 476
                   |::::.|.:.|..........|::.|.|:.....|...||::.......:.|
  Fly   320 -------TEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSSGGYTINN 377

Human   477 LRWPWQAAIYRRTSGVHDGSLHKGAW------FLVCSGALVNERTVVVAAHCVTDLGKVTMIKTA 535
            ...||...:|              .|      ...|.|:|:....|:.|||||.|.|........
  Fly   378 TVVPWHVGLY--------------VWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYD 428

Human   536 DLKVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLD--ADIAILKLLDKARISTRVQPICL 598
            ..:|:..||||:........:...:..|.:.|.|.....:  .|:|:|.|.:...:|..::|||:
  Fly   429 TFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICV 493

Human   599 AASRDLSTSFQESHITV-------AGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGI 656
            ..:     ||.|.....       ||||:                           |.:||...:
  Fly   494 TFA-----SFAEKESVTDDVQGKFAGWNI---------------------------ENKHELQFV 526

Human   657 PVSVTDNMFCASWEPTAPSD-----------ICTAETGGIAAVSFPGRASP---EPRWHLMGLVS 707
            |.....|..|........:|           .|..::||......|..|..   ..|..|.|::|
  Fly   527 PAVSKSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS 591

Human   708 WSYD-KTCSHRLSTAFTKVLPFKDWI 732
            .:.: ..|:|.| |..|.:..|:|.|
  Fly   592 NAPNADQCAHSL-TVMTNIQHFEDMI 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAMR1	NP_056245.2	CUB	128..234	CDD:238001	15/106 (14%)
		EGF_CA	240..272	CDD:238011	9/44 (20%)
		CCP	297..360	CDD:153056	23/67 (34%)
		CCP	<425..460	CDD:153056	6/34 (18%)
		Tryp_SPc	478..735	CDD:238113	62/285 (22%)
modSP	NP_536776.2	LDLa	27..58	CDD:197566	7/34 (21%)
		LDLa	70..101	CDD:197566	8/48 (17%)
		LDLa	123..157	CDD:197566	11/84 (13%)
		LDLa	167..199	CDD:238060	9/40 (23%)
		CCP	<251..284	CDD:153056	14/34 (41%)
		Tryp_SPc	371..616	CDD:214473	62/291 (21%)