DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POC1A and wds

DIOPT Version :9

Sequence 1:	NP_056241.3	Gene:	POC1A / 25886	HGNCID:	24488	Length:	407	Species:	Homo sapiens
Sequence 2:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	99/296 - (33%)
Similarity:	154/296 - (52%)	Gaps:	20/296 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPS 72
            ||:.:..|...|.|..:.|.:.|...|           :|| :...:||  ||..||:.|.|||:
  Fly    31 SLQPNSVGQPGATTSSNSSASNKSSLS-----------VKP-NYTLKFTLAGHTKAVSAVKFSPN 83

Human    73 GHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
            |..|||.|.||.::|| ..:.|.|.|: ..|...:..|.:.||.:..|:.|||||:|||.....|
  Fly    84 GEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGK 147

Human   137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
            .|.:|..|.|:|.|..|:|...||||.|.|::|::||..:.:|:.:...|...|:.|.|:..|:.
  Fly   148 SLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSL 212

Human   202 IAAAGMDNTVKVWDVRTHRLLQH-YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
            |.::..|...::||..:.:.|:. ....:..|:.:.|.|:|.|::.|:.|:|||:.|..:|:.|.
  Fly   213 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 277

Human   266 TLHGHQGPATTV--AFSRT-GEYFASGGSDEQVMVW 298
            |..||:.....:  .||.| |::..||..|..|.:|
  Fly   278 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIW 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1A	NP_056241.3	WD40	11..299	CDD:238121	98/295 (33%)
		WD 1	17..56		8/38 (21%)
		WD40 repeat	23..59	CDD:293791	8/37 (22%)
		WD 2	59..98		19/39 (49%)
		WD40 repeat	64..100	CDD:293791	17/36 (47%)
		WD 3	101..140		15/38 (39%)
		WD40 repeat	107..140	CDD:293791	14/32 (44%)
		WD 4	143..182		16/38 (42%)
		WD40 repeat	148..184	CDD:293791	14/35 (40%)
		WD 5	185..224		10/38 (26%)
		WD40 repeat	190..226	CDD:293791	9/36 (25%)
		WD 6	227..266		13/38 (34%)
		WD40 repeat	232..255	CDD:293791	9/22 (41%)
		WD 7	269..308		11/33 (33%)
wds	NP_001245503.1	WD40	64..358	CDD:238121	89/251 (35%)
		WD40 repeat	75..112	CDD:293791	17/37 (46%)
		WD40 repeat	118..154	CDD:293791	15/35 (43%)
		WD40 repeat	159..195	CDD:293791	14/35 (40%)
		WD40 repeat	202..237	CDD:293791	8/34 (24%)
		WD40 repeat	244..280	CDD:293791	14/35 (40%)
		WD40 repeat	288..325	CDD:293791	9/26 (35%)
		WD40 repeat	331..357	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920