Protein Alignment POC1A and Poc1

DIOPT Version :10

• Sequence 1: NP_056241.3
• Gene: POC1A / 25886
• HGNCID: 24488
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_001261799.1
• Gene: Poc1 / 39502
• FlyBaseID: FBgn0036354
• Length: 403
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 155/396 - (39%)
• Similarity: 234/396 - (59%)
• Gaps: 19/396 - (4%)

Human     8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
            ||:|||||.||...:|.:.|..:..|:|:.|.||.:::|::...:|..||..|...|..|.:||.
  Fly     7 DPALERHFTGHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPK 71

Human    73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
            |:|:||...|:||:||.|.::|.|..|.||:..||||.|.|.|...:||||||:.|:|...|::|
  Fly    72 GNLVASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQF 136

Human   138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCI 202
            :.|.:|..||||.|||||:|:|:.:|||||:|:::|..|.|||.::.|.......:.:||.|..:
  Fly   137 VSSFAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQLAWHPWGNML 201

Human   203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
            |.|...|.:|::||...:|||.|.:|||.||.::|||||::|::.|.|.|::||||:|||.:|||
  Fly   202 AVALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEGRPIYTL 266

Human   268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDF 332
            .||......|||||.|:.||:||||.|::||:||....|..:.    ...:.||||......|..
  Fly   267 TGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSNLHTYDASQF----EAKSALASSSCESSGVSS 327

Human   333 PVPPGRGRSVE---SVQSQPQEPVSVP------QTLTSTLE------HIVGQLDVLTQTVSILEQ 382
            ....|...|..   |::..|::.::..      |.|..::|      ....:||.:::.:..:::
  Fly   328 KQSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQVLDVSIESGSDLCSCSARLDEISKLLDSIDE 392

Human   383 RLTLTE 388
            |:...|
  Fly   393 RVRRLE 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POC1A	NP_056241.3	WD40	<6..298	CDD:441893	134/289 (46%)
		WD 1	17..56		11/38 (29%)
		WD40 repeat	23..59	CDD:293791	11/35 (31%)
		WD 2	59..98		17/38 (45%)
		WD40 repeat	64..100	CDD:293791	16/35 (46%)
		WD 3	101..140		19/38 (50%)
		WD40 repeat	107..140	CDD:293791	16/32 (50%)
		WD 4	143..182		23/38 (61%)
		WD40 repeat	148..184	CDD:293791	20/35 (57%)
		WD 5	185..224		12/38 (32%)
		WD40 repeat	190..226	CDD:293791	12/35 (34%)
		WD 6	227..266		21/38 (55%)
		WD40 repeat	232..255	CDD:293791	11/22 (50%)
		WD 7	269..308		20/38 (53%)
Poc1	NP_001261799.1	WD40	<7..298	CDD:441893	135/290 (47%)
		WD40 repeat	22..58	CDD:293791	11/35 (31%)
		WD40 repeat	63..99	CDD:293791	16/35 (46%)
		WD40 repeat	106..140	CDD:293791	16/33 (48%)
		WD40 repeat	147..183	CDD:293791	20/35 (57%)
		WD40 repeat	189..224	CDD:293791	12/34 (35%)
		WD40 repeat	231..254	CDD:293791	11/22 (50%)
		WD40 repeat	273..297	CDD:293791	13/23 (57%)