DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKD2 and SCH9

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_012075.1	Gene:	SCH9 / 856612	SGDID:	S000001248	Length:	824	Species:	Saccharomyces cerevisiae

Alignment Length:	320	Identity:	102/320 - (31%)
Similarity:	154/320 - (48%)	Gaps:	32/320 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   522 HA-PHRQASLSISVSNSQIQENVDIATVYQ------IFPDE-----VLGSGQFGVVYGGKHRKTG 574
            || .|:..||...|.:..:..::.|...|:      ..|.:     :||.|.||.||..|.:.|.
Yeast   371 HASQHQWHSLKPRVIDEVVSGDILIKWTYKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQ 435

Human   575 RDVAVKVIDKLRFPTKQESQ----LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML 635
            |..|:||:.|.....|.|..    .||.:....|...|.||.|:..|:||..:::|.:.:.|..|
Yeast   436 RIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGEL 500

Human   636 EMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFAR 700
            ...|..| ||..|...||.|.::::||.|||..:||:.||||||:||   |....:.|||||.::
Yeast   501 FWHLQKE-GRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILL---DANGNIALCDFGLSK 561

Human   701 IIGEKSFRRSVVGTPAYLAPEVLLNQ-GYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ--IQ 762
             ...|....:..||..|||||:||:: ||.:.:|.||:||:::....|..||..:   |:|  .|
Yeast   562 -ADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAE---NNQKMYQ 622

Human   763 NAAFMYPASPWSHISAGAIDLINNLLQVKMRKRY-SVD---KSLSHPWLQEYQTWLDLRE 818
            ..||.....|...:|......:..||....:.|. ::|   :..:||:..:.. |..|::
Yeast   623 KIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADID-WEALKQ 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247
		C1	265..314	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373
		PH_PKD	391..511	CDD:269945
		STKc_PKD	547..806	CDD:270984	92/280 (33%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	8/35 (23%)
SCH9	NP_012075.1	STKc_Sck1_like	418..738	CDD:270738	93/273 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910