DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRKD2 and PRK1

DIOPT Version :9

Sequence 1:NP_001073349.1 Gene:PRKD2 / 25865 HGNCID:17293 Length:878 Species:Homo sapiens
Sequence 2:NP_012171.1 Gene:PRK1 / 854713 SGDID:S000001357 Length:810 Species:Saccharomyces cerevisiae


Alignment Length:284 Identity:66/284 - (23%)
Similarity:117/284 - (41%) Gaps:81/284 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   557 LGSGQFGVVYGGKHRKTG--RDVAVKVIDKLRFPTKQE-SQLRNEVAILQSLRH----------- 607
            |.||.|..||..:.....  .:..:..:.::..|.||. :.||.||..::.||:           
Yeast    28 LTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSH 92

Human   608 -----PGIVNLECMFETPEKVFVVMEKL-HGDMLEMILSSEKGRLPERLTKFLITQILVALRHLH 666
                 .||.         .:|||:||.. .|.:::.:.:..:.||.|.....:::|.:..:..:|
Yeast    93 AARSVNGIA---------YEVFVLMEFCERGGLIDFMNTRLQNRLQESEILEIMSQTVQGITAMH 148

Human   667 FKN--IVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG---------------- 713
            ...  ::|.|:|.||||::....:   |:||||            ||.|                
Yeast   149 ALQPPLIHRDIKIENVLISHDGLY---KVCDFG------------SVSGVIRPPRNTQEFNYVQH 198

Human   714 ------TPAYLAPEVL-LNQG--YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYP 769
                  |..|.:||:: |.:|  .:...|:|::||.:|.....|.||.:..:..  |.:|.:.||
Yeast   199 DILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAG--ILHARYQYP 261

Human   770 ASP-WSHISAGAIDLINNLLQVKM 792
            :.| :|       |.:.||:::.:
Yeast   262 SFPQYS-------DRLKNLIRLML 278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRKD2NP_001073349.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
C1_1 139..188 CDD:278556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..247
C1 265..314 CDD:237996
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 343..373
PH_PKD 391..511 CDD:269945
STKc_PKD 547..806 CDD:270984 66/284 (23%)
Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269|PubMed:28428613 724..726 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 844..869
PRK1NP_012171.1 STKc_NAK_like 18..300 CDD:270939 66/284 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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