DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and SKM1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_014528.1	Gene:	SKM1 / 854036	SGDID:	S000005473	Length:	655	Species:	Saccharomyces cerevisiae

Alignment Length:	618	Identity:	141/618 - (22%)
Similarity:	234/618 - (37%)	Gaps:	144/618 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   314 CLGEALINGDVPMEEATDFSEADKS-------ALMDESEDSGVIPG----SHSENALHASEEEEG 367
            |..|.:::  ||:...|:.|.....       ...|:.|:...|..    |:|:.::..|...|.
Yeast    42 CNEEPVLS--VPLTSITNVSRIQLKQNCFEILRATDQKENISPINSYFYESNSKRSIFISTRTER 104

Human   368 E-GGKAQSSLGYIPLMRVVQSVRHTTRK------------------------SSTTLREGW---- 403
            : .|...:.....||:..|.|..:.|.|                        :|....:.|
Yeast   105 DLHGWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNS 169

Human   404 --VV-------HYSNKDTLRKRHYWR--LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 457
              |:       .|:..||::...:..  ||.|.:........|:....|..|...|:...:..|:
Yeast   170 KAVIKALQFYEDYNGLDTMQFNDHLNTSLDLKPLKSPTRYIINKRTNSIKRSVSRTLRKGKTDSI 234

Human   458 VP-----------PGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQAL--- 508
            :|           |..:.:.|..:..|.....|.:..........|..:..:..:..|:..|
Yeast   235 LPVYQSELKPFPRPSDDDYKFTNIEDNKVREEGRVHVSKESTADSQTKQLGKKEQKVIQSHLRRH 299

Human   509 ------MPVILQDAPSAPGHAPH----------------RQASLSISVSNSQIQENVDIATVYQI 551
                  .|..|  |||||....|                ...|..|.:....:..:|:....:|:
Yeast   300 DNNSTFRPHRL--APSAPATKNHDSKTKWHKEDLLELKNNDDSNEIIMKMKTVAIDVNPRPYFQL 362

Human   552 FPDEVLGSGQFGVVYGGK-----------------HRKTGRDVAVKVIDKLRFPTKQESQLRNEV 599
            .  |..|.|..|.||..|                 ||..|..||:|.|.....|.||  .:.||:
Yeast   363 V--EKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQ--LIMNEL 423

Human   600 AILQSLRHPGIVN-LECMFETPEKVFVVMEKLHG----DMLEMILSSEKGR----LPERLTKFLI 655
            .::...|...||| ||......|:::|:||.:.|    |:|:.:..|..|.    |.|....:::
Yeast   424 LVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIV 488

Human   656 TQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK-SFRRSVVGTPAYLA 719
            .:....|:.||.|.|:|.|:|.:|:||.|..   .||:.||||...:.|| |.|.::||||.::|
Yeast   489 KETCQGLKFLHNKKIIHRDIKSDNILLNSQG---LVKITDFGFCVELTEKRSKRATMVGTPYWMA 550

Human   720 PEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFM----------YPASPWS 774
            ||::..:||:..:|:||:|:::...:.|..|:     :|:....|.::          :|.|
Yeast   551 PEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPY-----LNEDPLKALYLIANNGSPKLRHPES--- 607

Human   775 HISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 807
             :|......::..|||.:..|.||.|.|:..:|
Yeast   608 -VSKQTKQFLDACLQVNVESRASVRKLLTFEFL 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247
		C1	265..314	CDD:237996	141/618 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		7/34 (21%)
		PH_PKD	391..511	CDD:269945	24/178 (13%)
		STKc_PKD	547..806	CDD:270984	87/295 (29%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869
SKM1	NP_014528.1	PH_Cla4_Ste20	4..113	CDD:270097	14/72 (19%)
		PBD	122..180	CDD:395634	7/57 (12%)
		STKc_PAK	359..640	CDD:270789	88/297 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910