DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and TPK1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_012371.2	Gene:	TPK1 / 853275	SGDID:	S000003700	Length:	397	Species:	Saccharomyces cerevisiae

Alignment Length:	384	Identity:	104/384 - (27%)
Similarity:	188/384 - (48%)	Gaps:	37/384 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   483 GGTPGGPSGQGAEAARGWETAIRQALMPVI-------------LQDAPSAPGHAPHRQASLSISV 534
            ||.......||.|:.:| ||:.|:......             .|:.|..|....:.:......:
Yeast     9 GGQKSLDDRQGEESQKG-ETSERETTATESGNESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFI 72

Human   535 SNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK-LRFPTKQESQLRNE 598
            :.:::.........:||.  ..||:|.||.|:..:.|..||..|:||:.| :....||.....:|
Yeast    73 AQARVTSGKYSLQDFQIL--RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDE 135

Human   599 VAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALR 663
            ..:|..:.||.|:.:...|:..:::|::|:.:.|..|..:|...: |.|..:.||...::.:||.
Yeast   136 RLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQ-RFPNPVAKFYAAEVCLALE 199

Human   664 HLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGY 728
            :||.|:|::.||||||:||   |....:|:.|||||:.:.:.::  ::.|||.|:||||:..:.|
Yeast   200 YLHSKDIIYRDLKPENILL---DKNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVVSTKPY 259

Human   729 NRSLDMWSVGVIMYVSLSGTFPFNEDEDIN--DQIQNAAFMYPASPWSHISAGAIDLINNLLQVK 791
            |:|:|.||.|:::|..|:|..||.:...:.  ::|.||...:|  |:  .:....||::.|:...
Yeast   260 NKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFP--PF--FNEDVKDLLSRLITRD 320

Human   792 MRKRY-----SVDKSLSHPWLQEYQTWLDL--RELEGKMGERYITHESDDARWEQFAAE 843
            :.:|.     ..:...:|||.:|. .|..|  |.:|..........:.|.::::::..|
Yeast   321 LSQRLGNLQNGTEDVKNHPWFKEV-VWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEE 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247
		C1	265..314	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373
		PH_PKD	391..511	CDD:269945	9/27 (33%)
		STKc_PKD	547..806	CDD:270984	83/266 (31%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		104/384 (27%)
TPK1	NP_012371.2	STKc_PKA_like	85..375	CDD:270732	91/302 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910