DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and PKC1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_009445.2	Gene:	PKC1 / 852169	SGDID:	S000000201	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	898	Identity:	190/898 - (21%)
Similarity:	330/898 - (36%)	Gaps:	249/898 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    96 FKHDPTSANLLQL-VRSSGDIQEGDLVEVVLSASATF----EDFQIRPHALTVHSYRAPAFCDHC 155
            |..:|:...||.| ...|..|:...|:..:....|..    |.|:...|.....|:.....|.:|
Yeast   367 FVLEPSGQILLTLGFHKSSQIERKQLMGGLHRHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYC 431

Human   156 GEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAE 220
            |:.   |...|.:|..|....||:|..::...|
Yeast   432 GDF---LRYTGFQCQDCKFLCHKKCYTNVVTKC-------------------------------- 461

Human   221 ELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLL 285
             :::::|:..|                      |:..|:. ::||.||..|......|..|..:|
Yeast   462 -IAKTSTDTDP----------------------DEAKLNH-RIPHRFLPTSNRGTKWCCHCGYIL 502

Human   286 KGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVI 350
            .....:..:|.:|...||.:||..||:.|        .:.||.|....:..:....::.:....:
Yeast   503 PWGRHKVRKCSECGIMCHAQCAHLVPDFC--------GMSMEMANKILKTIQDTKRNQEKKKRTV 559

Human   351 PGSHSENALHASEEEEGEGGK-AQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLR 414
            |.:...:::..:...:....| |:.:...:|    .|..:|.  |:.:..:.|       :|:..
Yeast   560 PSAQLGSSIGTANGSDLSPSKLAERANAPLP----PQPRKHD--KTPSPQKVG-------RDSPT 611

Human   415 KRHYWRLDCKCITLFQNNTTNRYYKEIPLSE--ILTVESAQ---NFSLVPPGTNPHCFEIVTANA 474
            |:|...:| |.|:| |.:...:..|.|..:|  :...|.||   .||......:|      |:|.
Yeast   612 KQHDPIID-KRISL-QTHGREKLNKFIDENEAYLNFTEGAQQTAEFSSPEKTLDP------TSNR 668

Human   475 TYFVGEMPGGTPGGPSGQGAEAARGWET-------------AIRQALMPVILQDAPSAPG--HAP 524
            ...          |.:....|.::.||:             |.|:.:...|.||:.....  ...
Yeast   669 RSL----------GLTDLSIEHSQTWESKDDLMRDELELWKAQREEMELEIKQDSGEIQEDLEVD 723

Human   525 H-----------------RQASLSIS---------------------VSNSQIQENVDIA----- 546
            |                 |:|.|:|.                     .|...:||.|.:|
Yeast   724 HIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQIEQDHASKEVLQETVSLAPTSTH 788

Human   547 ---TVYQIFPD----------------------------EVLGSGQFGVVYGGKHRKTGRDVAVK 580
               |..|..|.                            :|||.|.||.|...|.:.|.|..|:|
Yeast   789 ASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIK 853

Human   581 VIDK---LRFPTKQESQLRNEVAILQS-LRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS 641
            |:.|   ::....:.::...:|.:|.: .:||.:.||.|.|:|..:::..||.:.|.  :::...
Yeast   854 VLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGG--DLMWHV 916

Human   642 EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFAR---IIG 703
            :..||..|..||...::|:||::.|...:::.|||.||:||.   |...:|:.|:|..:   ..|
Yeast   917 QNQRLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLT---PEGHIKIADYGLCKDEMWYG 978

Human   704 EKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAF-- 766
            .::  .:..|||.::|||:|..|.|.:::|.|:.||::|..|....||:.|::  |::.||..
Yeast   979 NRT--STFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDE--DEVFNAILTD 1039

Human   767 --MYPASPWSHISAGAIDLINNLLQVKMRKRY-----SVDKSLSHPWLQ--EYQTWLDLRELEGK 822
              :||..    ::...:.:...||.....||.     ..|:.:..|:.:  .:...|:||.....
Yeast  1040 EPLYPID----MAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNLRVKPPY 1100

Human   823 MGERYITHESDDARWEQ-FAAE----HPLPG-------------SGLPTDRDL 857
            :.|  |....|.:.:|| |.:.    .|||.             |.:|.|.||
Yeast  1101 IPE--IKSPEDTSYFEQEFTSAPPTLTPLPSVLTTSQQEEFRGFSFMPDDLDL 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		2/22 (9%)
		C1	265..314	CDD:237996	15/48 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		2/30 (7%)
		PH_PKD	391..511	CDD:269945	27/137 (20%)
		STKc_PKD	547..806	CDD:270984	78/302 (26%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		8/27 (30%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	13/86 (15%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	17/66 (26%)
		STKc_PKC	828..1145	CDD:270722	89/331 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910