DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKD2 and PKH1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_010778.3	Gene:	PKH1 / 852101	SGDID:	S000002898	Length:	766	Species:	Saccharomyces cerevisiae

Alignment Length:	284	Identity:	90/284 - (31%)
Similarity:	133/284 - (46%)	Gaps:	48/284 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   555 EVLGSGQFGVVYGGKHRKTGRDVAVKVIDK---LRFPTKQESQLRNEVAILQSLR-HPGIVNLEC 615
            |.||.|.:..|.....|.:|:..||||:.|   :|  .|:...:..|...||.|. ..||..|..
Yeast   129 EQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIR--QKKVKYVTVEKLALQKLNGTKGIFKLFF 191

Human   616 MFETPEKVFVVMEKL-HGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPEN 679
            .|:....::.::|.. |||.|.:|  .:.|.|.|...::..:||:.|:..||...|:|.|:||||
Yeast   192 TFQDEASLYFLLEYAPHGDFLGLI--KKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPEN 254

Human   680 VLLASADPFPQVKLCDFGFARIIGEK--------------SFRRSVVGTPAYLAPEVLLNQGYNR 730
            :||   |...:|||.|||.|:|:.|:              :..:|.|||..|::|| |||..|..
Yeast   255 ILL---DKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPE-LLNDNYTD 315

Human   731 S-LDMWSVGVIMYVSLSGTFPFN-EDEDINDQ----IQNAAFMYPASPWSHISAG----AIDLIN 785
            | .|:|:.|.|:|..|:|..||. .:|.:..|    ||.|           .:||    ..||:.
Yeast   316 SRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYA-----------FTAGFPQIVKDLVK 369

Human   786 NLLQVKMRKRYSVDKSLSHPWLQE 809
            .||......|.::.:..:|.:..|
Yeast   370 KLLVRDPNDRLTIKQIKAHLFFHE 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247
		C1	265..314	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373
		PH_PKD	391..511	CDD:269945
		STKc_PKD	547..806	CDD:270984	89/279 (32%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869
PKH1	NP_010778.3	STKc_PDK1	123..391	CDD:270733	89/280 (32%)
PKH1	NP_010778.3	S_TKc	125..391	CDD:214567	89/280 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910