DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKD2 and DUN1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_010182.1	Gene:	DUN1 / 851457	SGDID:	S000002259	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	295	Identity:	107/295 - (36%)
Similarity:	166/295 - (56%)	Gaps:	34/295 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   557 LGSGQFGVVYGGKHRKTGRDVAVKVID-KLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETP 620
            ||:|.:.:|...|::|||:.||||:.. :.....|:..|.|.|..||..::||.||||...|..|
Yeast   206 LGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEP 270

Human   621 ------EKVFVVMEKL-HGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPE 678
                  :| ::|:||: .|::.|.|:  .|..|.:..:|.|..|:|..|::||.:||:|.|:|||
Yeast   271 ISKSQIQK-YLVLEKIDDGELFERIV--RKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPE 332

Human   679 NVLL----------ASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG 727
            |:||          ....|:.      |||:.|||.|:..||..|..::.|||:|:|||||..:|
Yeast   333 NILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKG 397

Human   728 YNRSLDMWSVGVIMYVSLSGTFPFNED---EDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQ 789
            |...:|:||.|||:||.|.|..||::.   ..:.:||..|.:.:.:..|..|....:.||:|||.
Yeast   398 YTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLV 462

Human   790 VKMRKRYSVDKSLSHPWLQEYQ----TWLDLRELE 820
            :...:||::|::|:|||..:.|    ..|:|:.|:
Yeast   463 LNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247
		C1	265..314	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373
		PH_PKD	391..511	CDD:269945
		STKc_PKD	547..806	CDD:270984	101/275 (37%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869
DUN1	NP_010182.1	FHA	36..136	CDD:238017
DUN1	NP_010182.1	STKc_CAMK	199..479	CDD:270687	101/275 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910