DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and prkd3

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	XP_685483.4	Gene:	prkd3 / 557337	ZFINID:	ZDB-GENE-130530-880	Length:	891	Species:	Danio rerio

Alignment Length:	900	Identity:	592/900 - (65%)
Similarity:	680/900 - (75%)	Gaps:	82/900 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MATAPSYPAGLPG----SPGPGSPPPPGGLELQSPPPLLP----------QIPAPGS---GVSFH 48
            |:.:.:.|..||.    |....:||.|.    .||.|.:|          .:|:|.|   ||||.
Zfish     1 MSASSTSPLTLPNPFVHSQHQTAPPTPS----PSPSPPVPLCVRLSNGNHSVPSPTSSIHGVSFL 61

Human    49 IQIGLTREFVLL-PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSS 112
            :|||||||.|.| |....|:.||.|.|||||||||||||:|||||||||:||..|.|:||.:.|:
Zfish    62 LQIGLTREMVTLDPHDLSLSSVKDLVCSIVDQKFPECGFFGLYDKILLFRHDLNSDNILQRLTSA 126

Human   113 GDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYH 177
            .:|.||||:||||||.||.||||||||||.||||:||.|||:|||||:|||||||||:|||||||
Zfish   127 EEIHEGDLIEVVLSAQATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYH 191

Human   178 KRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESL--PCTAEELSRSTTELLPRRPPSSSSS 240
            |||||.|||||||.||||||:.||.       |.|.|:  |..||..:.|..|..|.:.|    .
Zfish   192 KRCAFKIPNNCSGVRKRRLSNVSLP-------GPSLSVPRPAPAEHATSSLEEQRPHQEP----G 245

Human   241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKR 305
            ....|::||||.::||:|.:|||||||:||:|||||:||.||:|||||||||:||||||||||||
Zfish   246 KRIPSWSGRPIWMEKMVLGRVKVPHTFVIHTYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKR 310

Human   306 CATRVPNDCLGEALINGD--VPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEE---- 364
            ||::||.||||  :.||:  .|..::....|.|.|   |.:.|||        ..|..|||
Zfish   311 CASKVPKDCLG--VFNGEPASPGPDSDSTMEVDSS---DVNSDSG--------RGLDDSEEPTTP 362

Human   365 -----------------EEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDT 412
                             ||.....:.|:...||||||||||:||.|:|||.::|||:|||::||.
Zfish   363 EDKIFFMDSPFMDREKDEEPVKTISPSTSTNIPLMRVVQSVKHTKRRSSTVVKEGWMVHYTSKDN 427

Human   413 LRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYF 477
            ||||||||||.||:|||||::..:|||||||||||.||.|::|..:..|.|||||||:||...|:
Zfish   428 LRKRHYWRLDSKCLTLFQNDSGAKYYKEIPLSEILQVEVARDFGSLALGGNPHCFEIITATMVYY 492

Human   478 VGEMPGG------TPG-GPSGQGAEAARGWETAIRQALMPVILQDAPS---APGHA-PHRQASLS 531
            |||..||      :|. ...|.|.|.|:.||.|||||||||.:...||   |.|.: .|::.|:|
Zfish   493 VGENTGGPHLHIHSPALATGGVGLEVAQSWERAIRQALMPVPVTPQPSVGTAAGQSKDHKELSIS 557

Human   532 ISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLR 596
            ||||||||||||||:::||||.||||||||||:||||||||||||||:|||||:|||||||||||
Zfish   558 ISVSNSQIQENVDISSIYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLR 622

Human   597 NEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVA 661
            |||||||:|.|||||||||||||||:|||||||||||||||||||||.:||||:||||:||||||
Zfish   623 NEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSKLPERITKFLVTQILVA 687

Human   662 LRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
            ||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||.::
Zfish   688 LRHLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSK 752

Human   727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVK 791
            ||||||||||||||:||||||||||||||||||||||||||||.:||..|||.|.||||||||||
Zfish   753 GYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPTPWKDISAEATDLINNLLQVK 817

Human   792 MRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL 846
            |||||||||:|||||||:|||||||||.|.:.|||||||||||||||::|.||.|
Zfish   818 MRKRYSVDKTLSHPWLQDYQTWLDLREFETRRGERYITHESDDARWEKYAYEHSL 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		11/37 (30%)
		C1_1	139..188	CDD:278556	41/48 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		5/22 (23%)
		C1	265..314	CDD:237996	39/48 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		9/50 (18%)
		PH_PKD	391..511	CDD:269945	75/126 (60%)
		STKc_PKD	547..806	CDD:270984	233/258 (90%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		1/2 (50%)
prkd3	XP_685483.4	C1_1	153..202	CDD:278556	41/48 (85%)
		C1	270..319	CDD:237996	39/48 (81%)
		PH_PKD	406..533	CDD:269945	75/126 (60%)
		STKc_PKD	573..832	CDD:270984	233/258 (90%)
		S_TKc	581..833	CDD:214567	229/251 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860