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Protein Alignment PRKD2 and dkf-2

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_001256725.1	Gene:	dkf-2 / 180121	WormBaseID:	WBGene00012019	Length:	1095	Species:	Caenorhabditis elegans

Alignment Length:	950	Identity:	444/950 - (46%)
Similarity:	563/950 - (59%)	Gaps:	148/950 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    14 SPGPGSPPPPGGLELQSPPPLL-----------------PQIPAPG-----------SGVSFHIQ 50
            :|.|.....||..:.|.|..|:                 |..|.|.           ..::|.:|
Worm   168 TPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQ 232

Human    51 IGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGD 114
            .|:.::.:.:.... .|..::..|...:.:.:||.|...|.|.|||:|||..|.|:|||:.:|.|
Worm   233 SGIHKKSIAVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITTSSD 297

Human   115 IQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKR 179
            :.:|.|||||:.:....|...:.||.|.||||:.|.|||.|||:|||||:|||||.|||||||||
Worm   298 VTDGTLVEVVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYHKR 362

Human   180 CAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSAS 244
            ||..|||||:|:::||.|:..|:..:|..|..:|......|    |..|.|....|||:...:|:
Worm   363 CASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRHSRRE----SCLEALDAARPSSTLGGAAT 423

Human   245 ----------------------------SYTGRPI--ELDKMLLSKVKVPHTFLIHSYTRPTVCQ 279
                                        |::|||:  |:.:....|::|||||.:|||..|||||
Worm   424 PNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVPHTFQVHSYKLPTVCQ 488

Human   280 ACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC----------LGEALING------------ 322
            .||||||||.|||:||:|||:||||:|:..|..||          ||....:|
Worm   489 HCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGNTKASQFFLGSQADDGTSLTGSMDNLRM 553

Human   323 -DVPM--EEATDFSEADK--------------------SALMDESEDSGVIPG---SHSENALHA 361
             .||.  :::|..:..|:                    ||.:..||.|| .||   |.:.|||..
Worm   554 CSVPFGSDQSTSGASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSG-SPGPVVSFAANALSN 617

Human   362 SEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCI 426
            ..:::    ...|....|||||||.|.:.|.||::..|:|||:|||:::..:||:||||||.|.|
Worm   618 MPDDD----VISSESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGI 678

Human   427 TLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPG-TNPHCFEIVTANATYFVGEMPGGTPGGPS 490
            |::|:..|.||||||||:|||      |.|:.||. |..:.|||.|....||:    .|:|....
Worm   679 TMYQDENTTRYYKEIPLNEIL------NVSMSPPDKTADYLFEIRTGVCVYFI----SGSPSDEK 733

Human   491 GQGAEAARGWETAIRQALMPVILQ---------DAPSAP--GHAPHRQASLSISVSNSQIQENVD 544
            |...: |:.|.|||:.|||||..|         |....|  |...|..|         :||...:
Worm   734 GSSLD-AQSWTTAIQSALMPVTPQSSVVGGKRIDKLKVPTEGETGHLGA---------KIQTEHE 788

Human   545 IATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPG 609
            .:.:||||.:|||||||||.||||.||:.|:.||||:||||:||..:|..||.||.||:.:.|||
Worm   789 FSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKVDHPG 853

Human   610 IVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCD 674
            :|:...|.||.:::|||||||.|||||||||||||||.||.|:||:.|||.|||:||..||||||
Worm   854 VVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSERTTQFLVAQILEALRYLHHLNIVHCD 918

Human   675 LKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGV 739
            |||||:||.|...||||||||||||||||||||||||||||||||||||.|:|:|||||||||||
Worm   919 LKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGV 983

Human   740 IMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSH 804
            |:|||||||||||||||||||||||.||||.:||..||..||:.||.||||||.|||:|.|:.|.
Worm   984 IVYVSLSGTFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQ 1048

Human   805 PWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEH 844
            .|:|.|..|.|||.||..:|:|::||||||.||:.:..||
Worm  1049 IWMQNYTLWSDLRVLEKAVGQRFVTHESDDVRWQAYEKEH 1088

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.