DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and Prkd2

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_001239387.1	Gene:	Prkd2 / 101540	MGIID:	2141917	Length:	875	Species:	Mus musculus

Alignment Length:	879	Identity:	836/879 - (95%)
Similarity:	853/879 - (97%)	Gaps:	5/879 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASE 65
            ||.|||:|||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse     1 MAAAPSHPAGLPGSPGPGSPPPPGGLDLQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASE 65

Human    66 LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASAT 130
            ||||||||||||||||||||||||||||||||||||||||||||||:.|||||||||||||||||
Mouse    66 LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSAADIQEGDLVEVVLSASAT 130

Human   131 FEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRR 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 FEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRR 195

Human   196 LSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASS-YTGRPIELDKMLLS 259
            |||||||||||||||:||||||||||||||||:||||||||||||||:|| ||||||||||||:|
Mouse   196 LSSTSLASGHSVRLGSSESLPCTAEELSRSTTDLLPRRPPSSSSSSSSSSFYTGRPIELDKMLMS 260

Human   260 KVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDV 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 KVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDV 325

Human   325 PMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVR 389
            |||||.|:||||||::.||.||||||||||||:||||||||||||.|||||||||||||||||||
Mouse   326 PMEEAADYSEADKSSISDELEDSGVIPGSHSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVR 390

Human   390 HTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQN 454
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.|||
Mouse   391 HTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAVEPAQN 455

Human   455 FSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSA 519
            |||||||||||||||:|||.||||||.|||.||||||||.||.||||||||||||||||||||||
Mouse   456 FSLVPPGTNPHCFEIITANVTYFVGETPGGAPGGPSGQGTEAVRGWETAIRQALMPVILQDAPSA 520

Human   520 PGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK 584
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 PGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK 585

Human   585 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPER 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPER 650

Human   650 LTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT 714
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 LTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT 715

Human   715 PAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAG 779
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   716 PAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSG 780

Human   780 AIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEH 844
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||.||.
Mouse   781 AIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWDQFVAER 845

Human   845 PLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
                .|.|.:.||||||.||||:|||||||||:|
Mouse   846 ----HGTPAEGDLGGACLPQDHEMQGLAERISIL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		30/33 (91%)
		C1_1	139..188	CDD:278556	48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		20/23 (87%)
		C1	265..314	CDD:237996	48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		26/29 (90%)
		PH_PKD	391..511	CDD:269945	111/119 (93%)
		STKc_PKD	547..806	CDD:270984	257/258 (100%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		12/24 (50%)
Prkd2	NP_001239387.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		30/33 (91%)
		C1_1	139..188	CDD:278556	48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		20/22 (91%)
		C1	266..315	CDD:237996	48/48 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..374		34/41 (83%)
		PH_PKD	392..512	CDD:269945	111/119 (93%)
		STKc_PKD	548..807	CDD:270984	257/258 (100%)
		S_TKc	556..808	CDD:214567	250/251 (100%)
		Important for ABL1-mediated Tyr-718 phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q9BZL6	725..727		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972760
Domainoid	1	1.000	508	1.000	Domainoid score	I7423
eggNOG	1	0.900	-	-		E1_KOG4236
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9516
Inparanoid	1	1.050	1703	1.000	Inparanoid score	I2309
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48438
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		oto124822
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290