DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and prkd3

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	XP_002940552.3	Gene:	prkd3 / 100486348	XenbaseID:	XB-GENE-6036037	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	479/818 - (58%)
Similarity:	596/818 - (72%)	Gaps:	59/818 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    46 SFHIQIGLTREFV-LLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLV 109
            |..:||||:|||. :.|..:....||:||..:|:::.||.||.|:.:||.||:|:.:|.|:|:.:
Frog    12 SIRLQIGLSREFYQIQPCDANYNTVKKLAMDLVEKQHPEFGFLGVSEKIQLFRHNLSSQNVLERL 76

Human   110 RSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGL 174
            ..:..||||||:||||.||.:. ||.||||.|.||||::|||||:|||||:|||||||||.||||
Frog    77 FPNNFIQEGDLIEVVLPASVSL-DFSIRPHILLVHSYKSPAFCDYCGEMLWGLVRQGLKCQGCGL 140

Human   175 NYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLP--CTAEEL------SRSTTELLP 231
            ||||||||.|||||.|.::.:|||.|. :|:......:..:|  .:.|:|      ||...:|:.
Frog   141 NYHKRCAFKIPNNCRGVKRGQLSSRSF-TGNQTNKPKASPIPSGVSLEDLGAHYSDSRDIYQLIQ 204

Human   232 RRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCK 296
            ::|       ...|..||||..|...::||||||||.:|||||||:||.|::|||||||||:|||
Frog   205 KKP-------RVPSIIGRPIWKDCEEINKVKVPHTFQVHSYTRPTICQHCRRLLKGLFRQGMQCK 262

Human   297 DCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHS------ 355
            ||:||||:||...||::||||.....:...||..|...........:.||.....||.|
Frog   263 DCRFNCHRRCVEYVPDECLGEISHPDEEDAEEDIDSVRQTNLGTNHQDEDEMSFKGSESSDLSCN 327

Human   356 -ENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYW 419
             ||::..|              .:||||||||||||..:|:|..|.|||:||:::||::||:|||
Frog   328 IENSMFDS--------------NFIPLMRVVQSVRHNKKKNSYVLMEGWLVHFTSKDSMRKKHYW 378

Human   420 RLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPP--GTNPHCFEIVTANATYFVGEMP 482
            :||.||||||.|.:..:||||:|||:||.:|:....:...|  |..|||||::|....|:|||.
Frog   379 QLDSKCITLFHNESGGKYYKELPLSDILHIEAYDKNTSGRPLGGETPHCFELLTDTLVYYVGER- 442

Human   483 GGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISV--SNSQIQENVDI 545
                   |....::...|...|||||...:..:..|        :||...:|  .|.:.|:|:||
Frog   443 -------SSTHIDSGEKWYRMIRQALFAGMNDNTSS--------RASTKANVQGENGEYQQNLDI 492

Human   546 ATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGI 610
            :.:|||||||||||||||:||||||||||||||:|||||||||::|||||||||||||:||..|:
Frog   493 SHMYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKLRFPSRQESQLRNEVAILQNLRFHGV 557

Human   611 VNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDL 675
            |:||.|.||||::||||||||||||||||||:||:||||:|:||:||||.||:|||.||||||||
Frog   558 VDLEAMCETPERIFVVMEKLHGDMLEMILSSDKGKLPERITRFLVTQILTALQHLHSKNIVHCDL 622

Human   676 KPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVI 740
            ||||||||:.|||||:||||||||||||||||||||||||||||||||.|.||||||||||||||
Frog   623 KPENVLLATEDPFPQIKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNSGYNRSLDMWSVGVI 687

Human   741 MYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHP 805
            :||||||||||||||||||||||||||||.:||:.||..||||||:|||||:|||:||.|:||||
Frog   688 IYVSLSGTFPFNEDEDINDQIQNAAFMYPKNPWNEISNDAIDLINSLLQVKIRKRFSVHKALSHP 752

Human   806 WLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAE 843
            |:|::.|||||||||.::|:||||||||||||:::|.|
Frog   753 WMQDFNTWLDLRELETRVGQRYITHESDDARWQKYAKE 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556	40/48 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		4/22 (18%)
		C1	265..314	CDD:237996	35/48 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		8/36 (22%)
		PH_PKD	391..511	CDD:269945	53/121 (44%)
		STKc_PKD	547..806	CDD:270984	218/258 (84%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		479/818 (59%)
prkd3	XP_002940552.3	C1_1	109..155	CDD:365894	39/45 (87%)
		C1	231..280	CDD:237996	35/48 (73%)
		PH_PKD	351..461	CDD:269945	51/117 (44%)
		STKc_PKD	495..753	CDD:270984	218/257 (85%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I20832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010