DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKD2 and prkd1

DIOPT Version :9

Sequence 1:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_001120884.1	Gene:	prkd1 / 100151704	XenbaseID:	XB-GENE-487626	Length:	860	Species:	Xenopus tropicalis

Alignment Length:	881	Identity:	612/881 - (69%)
Similarity:	705/881 - (80%)	Gaps:	51/881 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    28 LQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELA--HVKQLACSIVDQKFPECGFYGLY 90
            :.:||.:.|..|| |:|:|..|||||:||.||||...||:  .|:::||||||||||||||||:|
Frog     1 MSAPPVIRPPSPA-GTGLSLQIQIGLSREPVLLPEPGELSLGAVREMACSIVDQKFPECGFYGMY 64

Human    91 DKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHC 155
            ||||||:|||.|.|:||||:|..|||||||:||||||||||||||||||||.|||||||||||||
Frog    65 DKILLFRHDPNSENILQLVKSEADIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHC 129

Human   156 GEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAE 220
            ||||:|||||||||:||||||||||||.|||||||.||||||:.||....|:|       ..:.|
Frog   130 GEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLTGLSSIR-------TLSVE 187

Human   221 ELSRSTTELLPRRPPSSS-----SSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQA 280
            .||.:..|.|.::.||.|     |.|.:..:.||||:|||..|:||||||||:|||||||||||.
Frog   188 PLSSAPDEPLLQKSPSESFLGRHSRSGSQLHIGRPIKLDKFFLTKVKVPHTFVIHSYTRPTVCQH 252

Human   281 CKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALING---DVPMEEATDFSEADKSALMD 342
            |||||||||||||||||||||||||||:|||::||||..|||   ||.|||.:|.:|: :...||
Frog   253 CKKLLKGLFRQGLQCKDCKFNCHKRCASRVPHNCLGEDAINGDLSDVMMEEGSDDNES-RPEDMD 316

Human   343 ES---EDSGVIPGSHSENALHASEEEEGEGGK---AQSSLGYIPLMRVVQSVRHTTRKSSTTLRE 401
            ||   :..|.|.|..|||......:::.:...   :.|:...||||||||||:||.||||:.::|
Frog   317 ESPTTDSEGSISGCRSENGEMQEPDQDQDASDRTISPSASNNIPLMRVVQSVKHTKRKSSSVMKE 381

Human   402 GWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHC 466
            ||:|||::||.:|||||||||.||||||||:|.::|||||||||||::|.|::.||:.||.||||
Frog   382 GWMVHYTSKDPMRKRHYWRLDSKCITLFQNDTGSKYYKEIPLSEILSLEPAKDLSLLCPGANPHC 446

Human   467 FEIVTANATYFVGE-MPGGTPGG------PSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAP 524
            |||.|||..|:||| :|...|..      .||.|.:.||.||.||:.|||||..:.|..  |...
Frog   447 FEITTANVVYYVGENLPQPVPPDMGNVMLTSGAGLDIARMWEIAIQHALMPVNPKGAND--GSTQ 509

Human   525 HRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPT 589
            ||..|:||||||.|:.|||||::||||||||||||||||:||||||||||||||:|:||||||||
Frog   510 HRDVSISISVSNCQVHENVDISSVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPT 574

Human   590 KQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFL 654
            ||||||||||||||:|.|.|:|||||||||||:|||||||||||||||||||||||||||:||||
Frog   575 KQESQLRNEVAILQNLHHQGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPERITKFL 639

Human   655 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLA 719
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   640 VTQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLA 704

Human   720 PEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLI 784
            ||||.|:||||||||||||||:||||||||||||||||:|||||||||||.:||..||..|||||
Frog   705 PEVLRNRGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISPDAIDLI 769

Human   785 NNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAE------ 843
            ||||||||||||||||:|:|||||:|||||||||||.|:|||||||||||.||:|::.:
Frog   770 NNLLQVKMRKRYSVDKTLNHPWLQDYQTWLDLRELECKIGERYITHESDDPRWQQYSEDCRLLYP 834

Human   844 -HPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
             |.||    |...:      |:|.:|:.|.||:|:|
Frog   835 PHLLP----PPSYE------PEDAEMRALEERVSIL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		2/6 (33%)
		C1_1	139..188	CDD:278556	44/48 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		7/27 (26%)
		C1	265..314	CDD:237996	44/48 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		8/35 (23%)
		PH_PKD	391..511	CDD:269945	76/126 (60%)
		STKc_PKD	547..806	CDD:270984	235/258 (91%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		6/24 (25%)
prkd1	NP_001120884.1	C1_1	113..162	CDD:365894	44/48 (92%)
		C1	237..286	CDD:237996	44/48 (92%)
		PH_PKD	371..498	CDD:269945	76/126 (60%)
		STKc_PKD	532..791	CDD:270984	235/258 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010