Protein Alignment COG4 and Cog4

DIOPT Version :10

• Sequence 1: NP_056201.2
• Gene: COG4 / 25839
• HGNCID: 18620
• Length: 789
• Species: Homo sapiens
• Sequence 2: NP_609413.1
• Gene: Cog4 / 34442
• FlyBaseID: FBgn0032258
• Length: 776
• Species: Drosophila melanogaster
• Alignment Length: 774
• Identity: 299/774 - (38%)
• Similarity: 469/774 - (60%)
• Gaps: 41/774 - (5%)

Human    44 QELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNL 108
            ::::...:|:..||..|..:|::||.:|..||:||..:.|....|..::.|:.:|...|..|..|
  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80

Human   109 AENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVI 173
            ||:||:|||:||||:.|..:..||..|::||..|..||..|:..||||::|.|..|:|.:|:.::
  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145

Human   174 ELSRQGKEGSMIDAN--LKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGL 236
            ..:....:||:...:  :|.|::|.::.:.::|::|..|.|..||..||||||||||:|.|..|:
  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210

Human   237 RKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYG-- 299
            .|||.|:|:::|:||::.|........::.|..:.:||.||.:.|..||:||.:|||:|.:||
  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275

Human   300 PGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNS------------------ 346
            ...|..::..||.|||.:|:.::.:|.|.|....:.:.|..:..|::
  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRK 340

Human   347 ----TTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKL 407
                :.:|:.|:|:|.|:.|:|:|:||.|||.||:::|:....|   :...|:.:.:..:..:|:
  Fly   341 PSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVE---TCVPEKEQFDIMERYEKI 402

Human   408 LNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSS 472
            :.|..|...|||::..|:.:|.|||.|:|.||:.|||||.||..||||||||:|::|.|.|||::
  Fly   403 MKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTT 467

Human   473 SSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKG 537
            .||:..||:||.....|:.||.:.|...|:.|:|:....     :..|.|.:.:||||||..:
  Fly   468 QSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYID-----LAQAYNAIQTSLQQGKLHS-- 525

Human   538 IESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSN 602
             ...|..:.:|||.|||.::.:|.|.||.:|:|.:....|.|....|:..  .||||::|.||.:
  Fly   526 -SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQM--LDSCLTELKAVRD 587

Human   603 KFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEF 667
            ..:..:..|:.:|.|:.|||::.||||.|.:.|||:.|||...|||.:.:||.||:.|:..:..|
  Fly   588 ALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLNSF 652

Human   668 KASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFA 732
            |.||||..||:|..::.:.|.::||:.:.|.:|||||||..|:|:|:|.:|||..|:|::|||..
  Fly   653 KNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMT 717

Human   733 RLSQMATILNLERVTEILDYWGP--NSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL 789
            |:||:||:|||:::||:.:||.|  |....:|.|||.|||..|.||.|||.||||||:|
  Fly   718 RISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COG4	NP_056201.2	COG4	192..501	CDD:462425	122/332 (37%)
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	122/333 (37%)