DRSC/TRiP Functional Genomics Resources

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Protein Alignment NIPBL and SCC2

DIOPT Version :10

Sequence 1:NP_597677.2 Gene:NIPBL / 25836 HGNCID:28862 Length:2804 Species:Homo sapiens
Sequence 2:NP_010466.3 Gene:SCC2 / 851761 SGDID:S000002588 Length:1493 Species:Saccharomyces cerevisiae


Alignment Length:1602 Identity:317/1602 - (19%)
Similarity:599/1602 - (37%) Gaps:366/1602 - (22%)


- Green bases have known domain annotations that are detailed below.


Human  1174 KKEKQKKRKAYEPKLTPEEMMDSSTFKR---FTASIE-------NILDNL----EDMDFTAFGDD 1224
            |.|.:|:|               ..|||   ||:|..       |.|:.|    :.:..|..|.:
Yeast    76 KNEAEKER---------------LVFKRPSNFTSSANSVDYVPTNFLEGLSPLAQSVLSTHKGLN 125

Human  1225 DEI-----------PQELLLGKHQLNELGSESAKI----KAMGIMDKLSTDKTVKVLNILEKNIQ 1274
            |.|           |:    .||:|..:.|.:..:    .:.....|.||..|:...|:.|:.:.
Yeast   126 DSINIEKKSEIVSRPE----AKHKLESVTSNAGNLSFNDNSSNKKTKTSTGVTMTQANLAEQYLN 186

Human  1275 DGSKLSTLLNHNNDTEEEERL--WRDLIMERVTKSADACLTTI-----NIMTSPNMPKAVYIE-- 1330
            |...:..::..:.::.|...:  |..|..::...:.: |||.:     ||..:|.:..::.|.  
Yeast   187 DLKNILDIVGFDQNSAEIGNIEYWLQLPNKKFVLTTN-CLTKLQMTIKNITDNPQLSNSIEITWL 250

Human  1331 ----DVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSS-------KAKRAKCSTHKQRVIV 1384
                ||:...|:::|..|:..|   .|.:.|..    .|||:       ...:...:.|::..|:
Yeast   251 LRLLDVMVCNIKFSKSSLKMGL---DDSMLRYI----ALLSTIVLFNIFLLGKNDSNLHRESYIM 308

Human  1385 MLYNKVCDIVSSLSEL------LEIQLLTDTTILQVSSMGIT--PFFVENVS------------- 1428
            ...|.:.|::.||..|      |:|:..|....|::....|.  ||..:||:             
Yeast   309 EPVNFLSDLIESLKILTIEYGSLKIEFDTFQEALELLPKYIRNGPFLDDNVTAKLVYIFSDLLMN 373

Human  1429 ----------------ELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNS 1477
                            .::..:..::.::|..:::.|..|:||:.:.:.:||| ||..:..|   
Yeast   374 NDIEATTNIQFQSFWDNVKRISSDILVSLFGSFDQQRGFIIEELLSHIEKLPT-KRIQKKLR--- 434

Human  1478 SDMDGEPMYIQMVTALVLQLIQCV--VHLPSSEKD---SNAEEDSNKKIDQDVVITNSYETAMRT 1537
             .:..:.:||...|..::.:::.:  ....:..||   .|.:...|:...|:..:.|..|....|
Yeast   435 -KVGNQNIYITDFTFTLMSMLENINCYSFCNQMKDIAPENIDLLKNEYKKQEEFLFNIVEHINDT 498

Human  1538 AQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTE 1602
               .|..|.|...:      .|.:.:|||||||..::.|:||..|.:||.|.:.|:..:|     
Yeast   499 ---ILERFFKNPSA------LRYVIDNFVQDLLLLISSPQWPVTEKILSSLLKRLLSVYS----- 549

Human  1603 MALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSGG-EDEIQQLQKALLDYLDEN---- 1662
                                   .|.....:||.|..|:.|. ...|..::.:..|:.|.|    
Yeast   550 -----------------------PSMQVSANIETICLQLIGNIGSTIFDIKCSTRDHEDNNLIKM 591

Human  1663 ---TETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEES-------------SEGTHHAKEIE 1711
               .||.|.  |.:.|       :..:...:.:|.::....             .|.|..|||  
Yeast   592 INYPETLPH--FFKSF-------EECIAYNETIKCRRSATRFLWNLRLGTILILEEYTKDAKE-- 645

Human  1712 TTGQIMHRAENRKKFLRSI--------IKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPF-- 1766
               ||:......||.|..|        ::...:.|||:|::              |.:.:..|  
Yeast   646 ---QIITVDNELKKILEQIKDGGLGPELENREADFSTIKLD--------------YFSILHAFEL 693

Human  1767 AQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAA 1831
            ...:|.||..||.:|.::.|.:|:.|:||||.:.:.|..||:...::..:|.||.|:|.||::|.
Yeast   694 LNLYDPYLKLILSLLAKDKIKLRSTAIKCLSMLASKDKVILSNPMVKETIHRRLNDSSASVKDAI 758

Human  1832 VELL----GRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCV-- 1890
            ::|:    ..|         ::|..:.....|..|.|||.|::|...:..|  |...:|::.|  
Yeast   759 LDLVSINSSYF---------EFYQQINNNYNDDSIMVRKHVLRINEKMYDE--TNDIVTKVYVIA 812

Human  1891 KMIRRVNDEE-GIKKLVNETFQKLWFTPT------PHNDKEAMTRKILNITDVVAACRDTGYDWF 1948
            :::.::.||| .|..:........|....      |...|| ::..:|.:...||...:.....|
Yeast   813 RILMKIEDEEDNIIDMARLILLNRWILKVHEVLDQPEKLKE-ISSSVLLVMSRVAIMNEKCSQLF 876

Human  1949 EQLLQNLLKSEEDSS---YKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLF 2010
            :..|...|.::|..|   |..:....|.|.|.||:.|::......:..|..|:....   :..|.
Yeast   877 DLFLNFYLLNKEAHSKEAYDKITHVLTILTDFLVQKIVELNSDDTNEKNSIVDKQNF---LNLLA 938

Human  2011 LFSKIRPQLMVK-HAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLM 2074
            .|:......:.| |...:.||:.:  ..::||...  :.::.......:.:..:.||..:|..|:
Yeast   939 KFADSTVSFLTKDHITALYPYMVS--DEKSDFHYY--ILQVFRCTFEKLANFKQKFLYDLETTLL 999

Human  2075 KLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPA 2139
            ..:.|..:..:...:..:.:|........:...||.:    .:|.|.....:..|..:.:.....
Yeast  1000 SRLPKMNVREIDEAMPLIWSVATHRHDTARVAKACSS----CLSHLHPYINKANNEEAAIVVDGK 1060

Human  2140 LLRSLFTVGALCRHFDFDLEDFKGNSKV-------NIKDKVLELLMYFTK----HSDEEVQTKAI 2193
            |.|.::......| |.|..   ..|.|:       .:.:.:.:.|:..:|    |....|..|.:
Yeast  1061 LQRLIYLSTGFAR-FCFPK---PSNDKIAFLQEGETLYEHITKCLLVLSKDKITHVIRRVAVKNL 1121

Human  2194 IGL-GFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNL-QTYLQEEDTRMQQADRD-- 2254
            ..| |    .||.|...:.|.:|.:.  ..::..:::|:.:|::| ..:|.||...::....:  
Yeast  1122 TKLCG----NHPKLFNSRHVLHLLDK--EFQSDQLDIKLVILESLYDLFLLEERKSVRNTGVNST 1180

Human  2255 -------WKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQG 2312
                   .||:.|...::...|   |:.|::...:|..:|:............|:.::.|.|..|
Yeast  1181 LSSNSILKKKLLKTNRVEFAND---GVCSALATRFLDNILQLCLLRDLKNSLVAIRLLKLILKFG 1242

Human  2313 LIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKD 2377
            ..:|...:|.:||:.......:|:.|.:.|.::.:||...:......|:..:  :..:|:|    
Yeast  1243 YTNPSHSIPTVIALFASTSQYIRHVAYELLEDLFEKYETLVFSSLSRGVTKA--IHYSIHT---- 1301

Human  2378 PVRGFRQDESSSALCSHLYSMIR-----GNRQHRRAFLI------SLLNLFDDTAKTDVTM---L 2428
                   ||.......|..|::.     |.:...:.|.:      |.|:...|...|:.::   :
Yeast  1302 -------DEKYYYKHDHFLSLLEKLCGTGKKNGPKFFKVLKRIMQSYLDDITDLTSTNSSVQKSI 1359

Human  2429 LYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENES--S 2491
            ..:..|::...:.:|.:.:.::..||:|                 .|:.||.......:|.|  |
Yeast  1360 FVLCTNISNITFVSQYDLVSLLKTIDLT-----------------TDRLKEVIMDEIGDNVSSLS 1407

Human  2492 DSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLL-LMLKQHLKN 2555
            .|||::|                   .|..:...|.:....|:....:...:||| ::.:..|||
Yeast  1408 VSEEKLS-------------------GIILIQLSLQDLGTYLLHLYGLRDDVLLLDIVEESELKN 1453

Human  2556 -LCGFSDSKIQKYSPS-ESAKVYDKAINRKTGVHF--HPKQT 2593
             ........|.|:|.. |:.:.|..  |.|...:|  |.|.|
Yeast  1454 KQLPAKKPDISKFSAQLENIEQYSS--NGKLLTYFRKHVKDT 1493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NIPBLNP_597677.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..340
PTZ00121 <476..1092 CDD:173412
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..946
PspC_subgroup_2 <597..832 CDD:468202
PxVxL motif. /evidence=ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:28167679 996..1009
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1047
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1060..1191 4/16 (25%)
SCC2 1263..2473 CDD:467937 261/1355 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1691..1710 5/31 (16%)
HEAT 1 1767..1805 14/37 (38%)
HEAT repeat 1811..1839 CDD:293787 9/31 (29%)
HEAT 2 1843..1881 9/37 (24%)
HEAT repeat 1848..1874 CDD:293787 8/25 (32%)
HEAT 3 1945..1984 12/41 (29%)
HEAT 4 2227..2267 9/49 (18%)
HEAT 5 2313..2351 9/37 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2473..2520 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2651..2696
SCC2NP_010466.3 SCC2 249..1435 CDD:467937 261/1347 (19%)
Blue background indicates that the domain is not in the aligned region.

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