DRSC/TRiP Functional Genomics Resources

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Protein Alignment NIPBL and mis4

DIOPT Version :10

Sequence 1:NP_597677.2 Gene:NIPBL / 25836 HGNCID:28862 Length:2804 Species:Homo sapiens
Sequence 2:NP_592917.2 Gene:mis4 / 2542657 PomBaseID:SPAC31A2.05C Length:1587 Species:Schizosaccharomyces pombe


Alignment Length:1845 Identity:365/1845 - (19%)
Similarity:699/1845 - (37%) Gaps:459/1845 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   953 LKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLI 1017
            |:|.:.|..|        .:.:.:::..|....:::  .|:.||.||               ..:
pombe    38 LQNVLYPSSK--------FQNEPLQLNSEESSIMQR--YVDMLNPGA---------------TFV 77

Human  1018 KDREDKS--RSSLKPIKNKPS----KSNKGSI-DQSV-----LKELPPELLAEIESTMPLCERVK 1070
            .|.|..:  :::|..:..:|:    :.|...: ||.|     |.||.....:.|:.:|.:||   
pombe    78 NDSETFNFYKNALSAMITEPAMPAMRVNASPVLDQKVCNSDSLSELNDFTKSLIQPSMLMCE--- 139

Human  1071 MNKRKRSTVNEKPKYAEISSDEDNDSDEAF--ESSRKRH---------------KKDDDKAWEYE 1118
                    ..|||..:.|:::. :.||..|  .||..|.               ||..|..    
pombe   140 --------PKEKPDASSINTNR-SSSDNGFLTPSSSPRSPSCSRVFNAVQLCSPKKSKDDI---- 191

Human  1119 ERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMED-YSPPPSLSEVARKMKKKEKQKKRK 1182
                                          .:|....||| |||..|.|::.|......||.:  
pombe   192 ------------------------------TTPKKRLMEDTYSPRESPSKIQRLQDVLLKQLQ-- 224

Human  1183 AYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMD----FTAFGDDDEIPQELLLGK----HQLN 1239
              :.:|...:::::              :|.||..    |....|||        ||    |.:.
pombe   225 --DTRLLISQVIEA--------------ENSEDFSSNSLFIKREDDD--------GKHISSHAIE 265

Human  1240 ELGSESAKIKAMGIMDKLSTD-KTVKVLNILEKNIQD-GSKLSTLLNHNNDTEEEERLWRDLIME 1302
            :|.....|:..:|..|||..: ..:.|..||||.::: .....:::|.::...:...|  |.|::
pombe   266 KLYMALTKLSRLGACDKLLEEGSIILVKQILEKELKELPVACYSIINLHDSLTQFPNL--DFILK 328

Human  1303 RVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLS 1367
                  ...|....|...|:..|....|.::         ||.|.|:..::  |.:......::.
pombe   329 ------TTALVLFIIFLVPSFKKLQNEESIL---------HLLNILHSIFE--YTVPEAIDNIVQ 376

Human  1368 SKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQL 1432
            ||...|:.| ..|.:.|:| .||.::::.||::.....|::..::::..:......::|..:.:|
pombe   377 SKTSDARTS-EIQHLSVLL-QKVANVLNILSKVAHEIPLSEAVVIRIVYLFPKVSTLDNSFKTKL 439

Human  1433 --C-----------AIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEP 1484
              |           ..:.:..:|..|...|..|:||..|:.:.|||::...|.:||::...    
pombe   440 PNCNSSSFDFLKAPLFQTLQYLFRLYPYQRDFIIEESLTNFSHLPTARSVSRTYRLSNGKS---- 500

Human  1485 MYIQMVTALVLQLIQ-CVVH-------LPSSEKDSNAEEDSN-----KKIDQDVVITNSYETAMR 1536
              ||..:.|.::||| |.:.       :.|..|.:.|....|     |.::.  :::.|.....|
pombe   501 --IQYYSTLFVRLIQSCSIQNLFDSEIVQSESKSTEALHSGNLTEHLKTVES--ILSKSRHEEYR 561

Human  1537 TAQNFLSIFLK---KCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSN 1598
            .|.:.::..|.   |....:.:..:..|.:..::|||:.::.|||...|.::......||...:|
pombe   562 IANHIVAYLLSRSLKQNKTESDNSFAILTKILLEDLLNMLSLPEWCGTETIIRQFAMNLVMTVTN 626

Human  1599 KSTEMALRVASLDYLGTVAARL---------RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKA 1654
            ....::.:.|:||.:..:..::         .|..:.:..:...|...:..::    .:.:|.:.
pombe   627 DKQAVSSKNAALDLISLIVNKVLALFDLSLFEKHNIPAPTNFNDIISFIPSIT----RLNELSQV 687

Human  1655 LLDYLDENTETDPSLVFSRKFYIAQWF------RDTTLETEKAMK---------SQKDEESSEGT 1704
            ..::.....:.|.||.....:...:||      |....::| |:|         .||.:|..:|.
pombe   688 SFNHFYFLCKGDISLENILPYNYNKWFSFLLQLRKVCNDSE-ALKIIDNCIDKNMQKSQEGFQGP 751

Human  1705 HHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYL----ASMRP 1765
            ...|..|....|         |:.|:..:  |.|..||.        ...||:.:|    ||:| 
pombe   752 SPFKADENDEDI---------FIISLYHS--SLFLNLKF--------FVSLIIGFLDSPQASLR- 796

Human  1766 FAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREA 1830
                     |:.||::.:         ||.:..::...|.:||:      :..:..|.|..||:.
pombe   797 ---------TKCLRIINQ---------MKTIPSILRTHPEVLAQ------IISKSNDQSAIVRDT 837

Human  1831 AVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRR 1895
            .::|||.:::...:...|.|..:|..|.|....||||.||.|.::...........::..|::.|
pombe   838 VLDLLGTYIMAYRETIPQIYGCIISGISDPSTIVRKRAIKQLCEVYEATEDLNIRVDIASKLLTR 902

Human  1896 VND-EEGIKKLVNETFQKLWFTPTPHN-------------DKEAMTRKILNITDVVAACRDTGYD 1946
            .|| ||.|.:|..|..:||||:|..:.             :|:.:..:...|..:.|......:.
pombe   903 SNDEEETISELSLEVLEKLWFSPASNELDCQKGYEQLTFLEKQKLRVQYFPILKLCAEPSTERHV 967

Human  1947 WFEQLLQNLLKSEED----SSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACIT 2007
            .....|:.:|.|:|:    :.:..::...:.|.:.|:|.:   .|...|...||:    |...::
pombe   968 LLVTSLKTMLTSKEEINLSTLHTQIRLLLSCLFNQLIEVV---TEDQVDESTKGI----LYEIMS 1025

Human  2008 TLFLFSKIRPQLM-VKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE 2071
            |||:||:..|.|. :.:...::|||.: .||..:...:..|..|...|:|..:..||:||.::|.
pombe  1026 TLFVFSRAFPFLFDLSYLHLLKPYLRS-ASTIEEQRFLYYVVAIFRQVLPFQKEISESFLRSLES 1089

Human  2072 DLMKLIIKYGMTVVQHCVSCLGAV---VNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSL 2133
            .|::.:.|.|...:...|.||.::   :|...:..|.|.:|..      |..:::|.|:      
pombe  1090 VLLQRLTKAGTATLMEIVPCLCSLFTRLNDYERLKKIVVSCLK------SLEEARHSEN------ 1142

Human  2134 LTNKPALLRSLFTVGALCRHFDFDL--EDFKGN---SKVNIKDKVLELLMYF---TKHSDEEVQT 2190
              |...::|.:..:|...|:.|.:.  :|:|.:   ......|..:.||.||   .|.:..:::.
pombe  1143 --NFQKMVRLIDLIGLFSRYGDLNRINDDWKHSLDFISPECDDAYVILLGYFQKLLKDAKGQLRI 1205

Human  2191 KAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKN---SSVNLK--IQVLKNLQTYLQEEDTRM-- 2248
            ..|..:....::..||.....:.:..:.|:::.|   .||..|  :::|...:..:.|.|.::  
pombe  1206 HIIDNMSRICLRETSLFISPLMLSTLDMIIAENNVNEVSVLFKSFLELLAADEDLIFEADQKLSL 1270

Human  2249 ---------QQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNV 2304
                     :..|||..|..|.:...|      |:|:|:||.:|..:|::.|..........:.:
pombe  1271 KGKQNVQSNKSVDRDMLKGTKDKQWIE------GVSASLMQHFLPCILDSCFSKNLRYSMLGIEI 1329

Human  2305 IALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQ 2369
            :...::|||::|..|...:||:.::.....|..|.....|:.:::...|.........:.:.:|:
pombe  1330 LKCIIHQGLVNPRMCFSTIIALESNAIKETREVAILLHTELHRRHESLIDGLYAQSADLIFSLQK 1394

Human  2370 AINTCLKDPVRGFRQDESS---SALCSHLYSMIRGNR--QHRRAFLISLLNLFDDTAKTD----- 2424
            .      :..:.|:..|.|   ||     |:::..::  :.|:..::.:|.    ..|.|     
pombe  1395 T------EEYQTFKLGEFSPFQSA-----YTIVSADKSSKSRKKLIMQILK----PLKLDGIDLP 1444

Human  2425 ------VTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSS 2483
                  |:.:.:....||..||.:.||||.|:..:|..|:..|..                    
pombe  1445 SFTEEKVSFVSFCCVCLAGIPYVSIEEPLMIISTVDSVLATIGPT-------------------- 1489

Human  2484 PSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLM 2548
                                               |...||.|......::...|:..    |:.
pombe  1490 -----------------------------------ITGWMKKLDHERFKILAGINLCN----LIY 1515

Human  2549 LKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRS 2613
            ||:::|.....|||              .:.|..|..:....:..:|.:.|| |...|   |.:.
pombe  1516 LKRYIKYAFSISDS--------------SRPIREKKPLTLLNRGYVDLITSD-AKPDI---VSKL 1562

Human  2614 IVKQYLDFKLLMEHLDPDEEEEEGE 2638
            ::|.:.:     |::...|::.|||
pombe  1563 VIKLFEE-----ENILSGEDQVEGE 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NIPBLNP_597677.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..340
PTZ00121 <476..1092 CDD:173412 29/150 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..946
PspC_subgroup_2 <597..832 CDD:468202
PxVxL motif. /evidence=ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:28167679 996..1009 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1047 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1060..1191 29/148 (20%)
SCC2 1263..2473 CDD:467937 272/1329 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1691..1710 7/27 (26%)
HEAT 1 1767..1805 5/37 (14%)
HEAT repeat 1811..1839 CDD:293787 7/27 (26%)
HEAT 2 1843..1881 12/37 (32%)
HEAT repeat 1848..1874 CDD:293787 12/25 (48%)
HEAT 3 1945..1984 7/42 (17%)
HEAT 4 2227..2267 10/52 (19%)
HEAT 5 2313..2351 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2473..2520 0/46 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2651..2696
mis4NP_592917.2 SCC2 290..1525 CDD:467937 281/1414 (20%)
HEAT repeat 780..808 CDD:293787 10/46 (22%)
HEAT repeat 818..846 CDD:293787 9/33 (27%)
HEAT repeat 855..881 CDD:293787 12/25 (48%)
HEAT repeat 892..921 CDD:293787 9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

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