DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POU2F3 and pdm2

DIOPT Version :9

Sequence 1:	NP_001231611.1	Gene:	POU2F3 / 25833	HGNCID:	19864	Length:	438	Species:	Homo sapiens
Sequence 2:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	189/499 - (37%)
Similarity:	236/499 - (47%)	Gaps:	136/499 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     2 ESPRTAKGGRDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDL-------------- 52
            |.|  |..||..:.:..|.    ...:.|...|...|:..|..:..:.|:|
  Fly   429 EQP--APNGRHCRPANKVM----RHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSS 487

Human    53 ---SDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNAS--PCQDMA------------SLHPLQQLV 100
               :..|...|.:....|:..|..::..|.....||  |.|.:|            .||...::|
  Fly   488 KRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMV 552

Human   101 -----------------LVPGHLQSVSQFLLSQTQPGQQGLQPNLLP---FPQQQSGLLLPQTGP 145
                             |:...||:::||...|....||...|  ||   .|..:|.|..|...|
  Fly   553 RQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDP--LPSYSTPLAKSPLRSPSLSP 615

Human   146 ---------------------GLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSG------- 182
                                 |::| |...|..|....:|.|:.|    .||  |:||
  Fly   616 VPRHSKSQQRTPPNSMTANSLGMSS-AVMTPNTPSMQQQPQLQQS----TPK--PTSGLTVASAM 673

Human   183 -----GADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFK 242
                 ..:|.:||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Fly   674 AKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFK 738

Human   243 NMCKLKPLLEKWLNDAESSPS---------DPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTL 298
            |||||||||:|||.||:|:.:         :...||.||.|  ..:.||:|||||||||.:|.||
  Fly   739 NMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTP--ESILGRRRKKRTSIETTVRTTL 801

Human   299 EKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRIN------CPVATPIKPPVYNSR 357
            ||.|..|.||:|||||.::|:|:|:|||:|||||||||||||||      .|..||:.
  Fly   802 EKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTGTPLS------- 859

Human   358 LVSPSGSLG--PLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSG 399
                |.:.|  |.::...|..|.|...|.|.       ||..||
  Fly   860 ----SHAFGYPPQALNMSHMQMEGGSGSFCG-------SSISSG 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU2F3	NP_001231611.1	POU	185..259	CDD:197673	67/73 (92%)
POU2F3	NP_001231611.1	Homeobox	286..339	CDD:278475	37/52 (71%)
pdm2	NP_001285877.1	POU	691..755	CDD:197673	60/63 (95%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	37/52 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4687
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm8655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.870