DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HECTD1 and Ufd4

DIOPT Version :9

Sequence 1:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens
Sequence 2:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster


Alignment Length:2893 Identity:1400/2893 - (48%)
Similarity:1802/2893 - (62%) Gaps:449/2893 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDES 65
            |.||||:||||||.||||||||||||||||||||||||||||||||:|||||||||||||||||.
  Fly     1 MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDEL 65

Human    66 APDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELI 130
            ||:|||||||||||||||||||||||||.:||||||:||.|||.:|::||||||||||:||||||
  Fly    66 APENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELI 130

Human   131 CTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLL 195
            ||||:|||||.|||||||:||||.|..||||||||||:||||||.|:||....::.||||||:||
  Fly   131 CTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195

Human   196 KHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGG------TVSG--PSS 252
            :|||..||||||:||||:||||||:.|||||||::|||.|||.|:.:.||      |.:|  |:|
  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260

Human   253 ACKPGRST-------------TGAPST---TADSKLSNQ-VSTIVSLLSTLCRGSPVVTHDLLRS 300
            :.:|..:|             |.:.||   ::|:..|.| :||.:|||||||||||.:|||:|||
  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325

Human   301 ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAG-STGRI-PGLRRLDSSGERSH 363
            :|.|::|.|||||||||||.||..||||:||||||:||.:.|.. :.|:: |..||.:::.:|:|
  Fly   326 QLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTH 390

Human   364 RQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRS 428
            |||||||||||::||.:||::|..:||.|||||||||||||||||.||||:|||:|||||:||||
  Fly   391 RQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQRS 455

Human   429 SSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARER---GHSEVVAILQSPGDWMCP-- 488
            ||||||||||||.:||.||:.||.||||||||||||||||||   ||.||.|||||||:||.|  
  Fly   456 SSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSPDH 520

Human   489 --VNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKASLALIRKM 551
              :|| |.||        ....||:|||||||||||.|||:|.:||..:||.|:|:||||||:|:
  Fly   521 SLLNK-DGKK--------YTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKI 576

Human   552 IHFC--------SEALLKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLLALQIIRDLVDKGG 608
            :.:.        ||....|...|..|.|...:|:|:.|:|||.|||.||||:.|.||.:::.|..
  Fly   577 VQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQ 641

Human   609 DIFLDQLARLGVISKVSTLAGPSSDD-------ENEEESKPEK------------EDEPQEDAKE 654
            :.|||..|||||.:||..|....:::       ..||.:..::            .|:|.|||||
  Fly   642 EEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKE 706

Human   655 LQQGKPYHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSE 719
            :.||||||||:|||.|||||||:|||:.|||||||||||||||:||||||||||||||.|:||||
  Fly   707 ILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSE 771

Human   720 SRSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKED 784
            :|.||||||.|||..|.....|||||......:|.||||.|...|..::.|||::|.|.|:|::|
  Fly   772 NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDD 836

Human   785 LPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVE 849
            ||||:|||||||||:|:|||.||.:|.:||:..:.::.|||.|..|.:||.::|::|:.:||:.:
  Fly   837 LPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQ 901

Human   850 SMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLLKDENTISPYEMCSS 914
            .:|||.|..|.:|..|:|.|:|    .|.:.....|...:..||..|..|:.::..:|.|||.||
  Fly   902 IIPRGAVAILTDIVKQIELSFE----EQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSS 962

Human   915 GLVQALLTVLN-NSMDLDMKQDCSQ---LVERINVFKTAFSEN--EDDESRP-----AVALIRKL 968
            ||||||:.||: |..:.:..: |.:   ..:|::|||....|:  |...::|     |..||:||
  Fly   963 GLVQALVAVLSVNHWETNSPR-CKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKL 1026

Human   969 IAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRMLKMEPLATVESLEQ 1033
            ::||||.|:||::|||:|.:.|:||||.:|||||||||..|:.|.||:||.||||||||:..|.:
  Fly  1027 VSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSK 1091

Human  1034 YLLKMVAKQWYDFDRSSFVFVRKLREGQN-FIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYG 1097
            ||||||||||||.|||::.:::|:||.:. .:|.|..||||.|::::||:||||. :|||||.||
  Fly  1092 YLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTC-DWVNPAQYG 1155

Human  1098 LVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGLWVIPSAYTLRHARGYGRSA 1162
            ||.||||||:.||||:||||||||:.:||||:.|:|.||||||||:::||:||||||||||||||
  Fly  1156 LVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSA 1220

Human  1163 LRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPLDPPKDEKQGWRHVRIKQMGKNASGQTH 1227
            ||||:.|.||||..||:|.|||||.||.|||||||||::...|:...:||:||:|.|:|||||||
  Fly  1221 LRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTH 1285

Human  1228 YLSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQD 1292
            ||||||||:||.|.||.:| :||:.|||||..||:||.:|:| ||:|..|||||||:||:|.:||
  Fly  1286 YLSLSGFEIYGRVVGVADD-IGKSVKEAEAKTRRERRQIRAQ-LKHMTTGARVIRGVDWRWEEQD 1348

Human  1293 GSPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLA-----PGYD------------- 1339
            |.  .|||:|||:|||||||.||.|..||||||||||:|||||     ..:|             
  Fly  1349 GC--AEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAK 1411

Human  1340 -----PDTVASPKPVSS-------------------TVSGTTQSWSSLVKNNCPD-----KTS-- 1373
                 .:|:.|.|..|:                   |||....:|...|:....:     ||.  
  Fly  1412 PSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQII 1476

Human  1374 ----AAAGSSSRKGSS---SSVCSVASSSDISLGSTKTERRSEIVMEHSIVSG------------ 1419
                |...||||:..:   .|..:.....:|| |.:...|..|.:.:.|.::.            
  Fly  1477 SNQLAMNTSSSREARAKHKESGTNQMHKDNIS-GPSPLSRELEHISDLSAINNSMPAINSSNVSD 1540

Human  1420 -ADVHEPIVVLS-SAENV---------PQTEVGSSSSASTSTLTAETGSEN---------AERKL 1464
             |.:.|.:.:.. |.||:         |...|.:|.|:|...:.:.:..||         ...|:
  Fly  1541 LATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKM 1605

Human  1465 GPDSSVR---------------------TPGESSAISM------GI------------------- 1483
            ..::||.                     |...:.|:.|      |:                   
  Fly  1606 NANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVP 1670

Human  1484 ---VSVSSPDVSSVSELTNKEAASQR---------PLSSS---------ASNRLSVSSLL----- 1522
               |.|..........|.|.:.|:|:         |..||         |....:|.|::     
  Fly  1671 CTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQ 1735

Human  1523 -----AAGAPMSSSASVPNLSSRETSSLES---------FVRRVANIAR------TNATNNM--- 1564
                 ....|...|.|||||::...|.:.|         .:...|.|||      ||..:|.   
  Fly  1736 PISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMN 1800

Human  1565 ---NLSRSSSDNNTNT-LGRNVMSTA---------TSPLMGAQSFPNLTTPGTTSTVTMSTSSVT 1616
               |::.....|.:.: ||.:|.|..         :..|..|||:|:|:: ..:..:..|..|.|
  Fly  1801 AEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSS-NNSENIAPSNPSNT 1864

Human  1617 SSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDL 1681
            |:...:.:|        :::|||.|||||||:|:     :.||.|||:||||..||.:|||::|:
  Fly  1865 SAGQQSAST--------INHTLTMSLTSTSSDSE-----QVSLEDFLESCRAPALLGDLDDEDDM 1916

Human  1682 PEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGSRPIGEQ 1746
            .| |.:::||||      ||||                       |.:.|.||..........:.
  Fly  1917 DE-DNDEEENED------EYEE-----------------------VGNTLLQVMVSRNLLTFMDD 1951

Human  1747 EEEEYETKG-GRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT--PHSELLEE 1808
            |..|....| .:|::|||::|||||||||:||||||||||||.||:||||.|.|.  |..:....
  Fly  1952 EAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGG 2016

Human  1809 VECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYT 1873
            .|....|.|.|.|:..|:|...|||:.|:|...|||..||:|||  |:...|.||.|:|||||||
  Fly  2017 PETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQ--CSQLNKLDKFRKIWEPTYT 2079

Human  1874 IMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSI 1938
            |:|||:....:|..     |         |.::|.|:...::                       
  Fly  2080 IVYREVSPEAQEST-----C---------LESEEFPQTPDVS----------------------- 2107

Human  1939 RKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQNSCGVEDVLQL 2003
                                :|||     .|||..:..:::...    .|.|  |.|.|:|||:|
  Fly  2108 --------------------SKSG-----ASTLSPNSPMHIGFN----VADN--NLCSVDDVLEL 2141

Human  2004 LRILYIVASDPYSRISQEDGD----EQPQFTFPPDEFTSKKITTKILQQIEEPLALASGALPDWC 2064
            |..:        :.::|.:.|    |........|.|.|||||.|:.|||::||.|||.|||:||
  Fly  2142 LTQI--------NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWC 2198

Human  2065 EQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTR-TTSSVRRDDPGEFRVGRL 2128
            |.|...||||.|||||||||.||:|||||:||.||::|:.||||.| ...|.|||| .|||:|||
  Fly  2199 ENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDD-HEFRIGRL 2262

Human  2129 KHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGAW 2193
            |||||||||.|.|:.||..||:.|.:||||||||||.|||||||||||||||||||.||:||..|
  Fly  2263 KHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMW 2327

Human  2194 LCDDNFPDD-ESRHVDLGGGLKPPGYYV-QRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCI 2256
            ||||:..:| |:......|..||.|||| :|..|:|.||.||:|:..|.:.|.|.|.|:|:||.:
  Fly  2328 LCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVL 2392

Human  2257 QDNRLVDLPISKPFFKLMCMGDIKS-NMSKLIYESR-GDRDLHCTESQSEASTEEGHDSLSVGSF 2319
            ||.||||:|:|..|.:|:|...:.| |:.|:|.:.| ||                    |||.|.
  Fly  2393 QDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGD--------------------LSVVSE 2437

Human  2320 EED--SKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSED 2382
            :.|  .....:|.....|..| |.|||:.|:.:.::|.|.:||:|:::|.::::.|..:..:|.:
  Fly  2438 DSDIVETCTKLLRTDSNKSNA-FGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAE 2501

Human  2383 EKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVD 2447
            :|:..:.||.|:..:|.  .:|:|||.|.|.:.|||.|||:|..:|.|:|....:|:||.|.|.:
  Fly  2502 KKHELINELKLQTQNGL--EVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCE 2564

Human  2448 LMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLG 2512
            |:.:|.:..||.:||:||.||||:|||::||::|:..|.:|::||.|.|.|:.||||:|||||||
  Fly  2565 LLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLG 2629

Human  2513 YTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVN 2577
            |.:|||||.|||.||..||.||||||||||||||:|||||||||||||||||||||...||||||
  Fly  2630 YNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVN 2694

Human  2578 TCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610
            |||||||||:|.:||||:||||.||.|||||||
  Fly  2695 TCVHYLKLPDYPTEEIMKERLLTATKEKGFHLN 2727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269 9/40 (23%)
Ank_2 366..457 CDD:403870 70/90 (78%)
ANK repeat 366..393 CDD:293786 16/26 (62%)
ANK 1 395..424 25/28 (89%)
ANK repeat 396..426 CDD:293786 25/29 (86%)
ANK 2 426..455 22/28 (79%)
ANK repeat 428..457 CDD:293786 22/28 (79%)
ANK 3 459..491 26/38 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513 7/23 (30%)
ANK 4 579..612 15/32 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748 27/40 (68%)
Sad1_UNC 1107..1240 CDD:400199 94/132 (71%)
MIB_HERC2 1277..1335 CDD:399589 42/57 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 19/95 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 15/94 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 21/83 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 17/19 (89%)
BTHB 1892..1965 CDD:408209 7/72 (10%)
K-box 2029..2103 47/73 (64%)
HECTc 2131..2608 CDD:238033 255/482 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 3/20 (15%)
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 16/26 (62%)
ANK 396..509 CDD:238125 87/112 (78%)
ANK repeat 422..453 CDD:293786 26/30 (87%)
ANK repeat 455..484 CDD:293786 22/28 (79%)
F5_F8_type_C 1173..1298 CDD:329041 89/124 (72%)
MIB_HERC2 1333..1389 CDD:310955 42/57 (74%)
DamX 1576..>1725 CDD:330571 21/148 (14%)
HECTc 2265..2725 CDD:238033 255/482 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152578
Domainoid 1 1.000 626 1.000 Domainoid score I174
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9115
Inparanoid 1 1.050 2241 1.000 Inparanoid score I40
Isobase 1 0.950 - 0 Normalized mean entropy S5221
OMA 1 1.010 - - QHG52632
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 1 1.000 - - FOG0006411
OrthoInspector 1 1.000 - - oto88780
orthoMCL 1 0.900 - - OOG6_107049
Panther 1 1.100 - - LDO PTHR45670
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3704
SonicParanoid 1 1.000 - - X4675
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

Return to query results.
Submit another query.