Protein Alignment BACE2 and cathD

DIOPT Version :9

• Sequence 1: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_001334713.1
• Gene: cathD / 45268
• FlyBaseID: FBgn0029093
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 95/374 - (25%)
• Similarity: 150/374 - (40%)
• Gaps: 93/374 - (24%)

Human    92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTP-H-----SYIDTYFDTERSSTYRSKGFDVTVKYT 150
            ||..:.||:|||..:::.||||||..|.... |     ..:...:|..:|.||...|.:..::|.
  Fly    73 YYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYG 137

Human   151 QGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGI-----KWNGILGLAYATLA----K 206
            .||.:|::..|.|:|..       ::|.....:|....||:     |::|||||.|.:::    |
  Fly   138 SGSLSGYLSTDTVSIAG-------LDIKDQTFAEALSEPGLVFVAAKFDGILGLGYNSISVDKVK 195

Human   207 PSSSLETFFDSLVTQANI-PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKE 270
            |.      |.::..|..| ..|||..     |....:...||.::.||.:|:.|.|:..|.|:..
  Fly   196 PP------FYAMYEQGLISAPVFSFY-----LNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTR 249

Human   271 EWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP--------QKVFDAVV---EAVA 324
            :.|:||::....||...|   |:  ...:.|.|:||:|:..|        ||:....:   :.|.
  Fly   250 KAYWQIKMDAASIGDLQL---CK--GGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVV 309

Human   325 RASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMG--- 386
            ...|||:                       .|.|...|    ..::|.:.....:.....||
  Fly   310 SCDLIPQ-----------------------LPVIKFVL----GGKTFELEGKDYILRVAQMGKTI 347

Human   387 -----AGLNYECYRFGISPSTNAL-VIGATVMEGFYVIFDRAQKRVGFA 429
                 .||:       |.|....| ::|...:..:|..||....|||||
  Fly   348 CLSGFMGLD-------IPPPNGPLWILGDVFIGKYYTEFDMGNDRVGFA 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	95/374 (25%)
		Asp	92..430	CDD:278455	95/374 (25%)
cathD	NP_001334713.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810