Protein Alignment BACE2 and Bace

DIOPT Version :9

• Sequence 1: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 362
• Identity: 103/362 - (28%)
• Similarity: 155/362 - (42%)
• Gaps: 65/362 - (17%)

Human    82 DNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTY 138
            :.|.......||..:.||||.|..::|.|:||||..|        |...|:    .:|:..||||
  Fly    59 EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHN----QYDSSASSTY 119

Human   139 RSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWN-----GILG 198
            .:.|...:::|..||.||::..|.|.:     ....:...|..||.|  .||..:|     ||||
  Fly   120 VANGESFSIQYGTGSLTGYLSTDTVDV-----NGLSIQSQTFAESTN--EPGTNFNDANFDGILG 177

Human   199 LAYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262
            :||.:||  ...:...|.::|:|..:.| |||..     |...|:.|.||.|:.||.:.|||.|.
  Fly   178 MAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFY-----LARDGTSTMGGELIFGGSDASLYSGA 235

Human   263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327
            :.|.||.|:.|:|..:....|.|.||..||      :||.|:||:|:..|...:      :..:.
  Fly   236 LTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSLIVAPYNAY------ITLSE 288

Human   328 LIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYE 392
            ::....||:...|.:          |..|.::..:...|      ..:.|..||....|     .
  Fly   289 ILNVGEDGYLDCSSV----------SSLPDVTFNIGGTN------FVLKPSAYIIQSDG-----N 332

Human   393 CYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 429
            |........|:..::|...:..:|..||....|:|||
  Fly   333 CMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	102/355 (29%)
		Asp	92..430	CDD:278455	102/352 (29%)
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	101/360 (28%)
		Asp	68..371	CDD:278455	102/353 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740