DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAJB5 and P58IPK

DIOPT Version :9

Sequence 1:	NP_001128477.1	Gene:	DNAJB5 / 25822	HGNCID:	14887	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_649916.1	Gene:	P58IPK / 41161	FlyBaseID:	FBgn0037718	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	156	Identity:	58/156 - (37%)
Similarity:	78/156 - (50%)	Gaps:	22/156 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    32 EDFLASLMFKIQLEPLKLRAWTLNGFVKFRNKETSAGPVAVMGKDYYKILGIPSGANEDEIKKAY 96
            :|.:.|....:.||....||.......|...|::..       :|||||||:...|::.||.|||
  Fly   359 DDAIHSFQAALDLEESNTRAKEGIQRAKKLQKQSER-------RDYYKILGVKRSASKQEIVKAY 416

Human    97 RKMALKYHPDKNKEPN---AEEKFKEIAEAYDVLSDPKKRGLYDQYGEEGLKTGGGTSGGSSGSF 158
            ||.|.|:|||..::..   ||:||.:||.|.:||:||:||..:|. ||:.|.......||
  Fly   417 RKAAQKWHPDNFRDEEKKVAEKKFIDIAAAKEVLTDPEKRRQFDN-GEDPLDPESNQRGG----- 475

Human   159 HYTFHGDPHATFASFFGGSNPFDIFF 184
               |||: | .|..|..|| ||...|
  Fly   476 ---FHGE-H-PFGHFQHGS-PFQFKF 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAJB5	NP_001128477.1	DnaJ	72..415	CDD:223560	50/116 (43%)
P58IPK	NP_649916.1	TPR_11	42..108	CDD:290150
		TPR repeat	43..71	CDD:276809
		TPR repeat	76..106	CDD:276809
		TPR_11	78..142	CDD:290150
		TPR repeat	111..139	CDD:276809
		TPR_1	113..144	CDD:278916
		TPR_19	167..234	CDD:291240
		TPR repeat	190..220	CDD:276809
		TPR repeat	225..253	CDD:276809
		TPR repeat	309..337	CDD:276809
		TPR_11	312..373	CDD:290150	3/13 (23%)
		TPR repeat	341..371	CDD:276809	2/11 (18%)
		TPR repeat	376..399	CDD:276809	6/29 (21%)
		DnaJ	395..>485	CDD:223560	44/100 (44%)
		DnaJ	396..460	CDD:278647	33/63 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910