DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAJB5 and Tpr2

DIOPT Version :9

Sequence 1:	NP_001128477.1	Gene:	DNAJB5 / 25822	HGNCID:	14887	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_001260501.1	Gene:	Tpr2 / 34984	FlyBaseID:	FBgn0032586	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	59/166 - (35%)
Similarity:	73/166 - (43%)	Gaps:	45/166 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    44 LEPLKLRAWTLNGFVKFRN---------------------KETSAGPVAVMGKDYYKILGIPSGA 87
            |:.|.|||...|...||..                     :|..........|||||||||...|
  Fly   349 LKALLLRARCYNDLEKFEESVADYETALQLEKTPEIKRMLREAKFALKKSKRKDYYKILGIGRNA 413

Human    88 NEDEIKKAYRKMALKYHPDKNKEPNAEE------KFKEIAEAYDVLSDPKKRGLYDQYGEEGLKT 146
            ::|||||||||.||.:|||::...:|||      ||||:.|||.:|||..|:..||        :
  Fly   414 SDDEIKKAYRKKALVHHPDRHANSSAEERKEEELKFKEVGEAYAILSDAHKKSRYD--------S 470

Human   147 GGGTSGGSSGSFHYTFHGDPHATFASFF----GGSN 178
            |..........|      ||:..|.:||    ||.|
  Fly   471 GQDIEEQEQADF------DPNQMFRTFFQFNGGGRN 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAJB5	NP_001128477.1	DnaJ	72..415	CDD:223560	50/117 (43%)
Tpr2	NP_001260501.1	TPR_11	49..114	CDD:290150
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		TPR_11	201..262	CDD:290150
		TPR repeat	201..225	CDD:276809
		TPR_1	231..264	CDD:278916
		TPR repeat	231..259	CDD:276809
		TPR_11	278..345	CDD:290150
		TPR repeat	310..344	CDD:276809
		TPR_11	314..380	CDD:290150	8/30 (27%)
		TPR repeat	349..377	CDD:276809	8/27 (30%)
		DnaJ	401..>503	CDD:223560	50/114 (44%)
		DnaJ	402..469	CDD:278647	37/66 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910