Protein Alignment ARIH1 and ari-2

DIOPT Version :9

• Sequence 1: NP_005735.2
• Gene: ARIH1 / 25820
• HGNCID: 689
• Length: 557
• Species: Homo sapiens
• Sequence 2: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 179/567 - (31%)
• Similarity: 284/567 - (50%)
• Gaps: 91/567 - (16%)

Human     1 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDGLLCGE 65
            ||||    .|.|     .|.|:..|.::|.|.....:|.    :||.::
  Fly     1 MDSD----IEMD-----MESDNDGEYDDDYDYYNTGEDC----DVERLD---------------- 36

Human    66 TGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATI 130
                                     |.....|.:.||.||.|.|.:.:.|.:.::|.::|...::
  Fly    37 -------------------------PKRADPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSL 76

Human   131 TRILLSHFNWDKEKLMERY-FDGNLEKLFAECHVINPSKKSRTRQMNTRSSA------------- 181
            .::||....|:...::|:| .|.|...:.|.   |.|...:.|...:|.::|
  Fly    77 AKVLLLEHQWNNVAVVEKYRQDANALLVTAR---IKPPSVAVTDTASTSAAAASAQLLRLGSSGY 138

Human   182 ----------QDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGC 236
                      :...|.:|..:.....|..|.|||.||..||:.|..|:|. :|:...|.|.|..|
  Fly   139 KTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMC 202

Human   237 DILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CG 300
            ::.|.::.|:.|:|...::.|||......:|:.:..|::||.|:|..:|:.....||...|| |.
  Fly   203 NVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACH 267

Human   301 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQ 365
            ..|||.||.::|.|..|:.:|||:.||.|||||:|:|:|:||:|||||:.|||:||||||.|  .
  Fly   268 TGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--F 330

Human   366 NCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRF 430
            |||.:|||:|||.|:.|||.:|.|:||.::...|......::|.||::||.|..|:.||.:||:.
  Fly   331 NCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKL 395

Human   431 EHKLYAQVKQKM-EEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENN 494
            |.:...:::|:: .::...:.:||:.|:|..|..:|.:||.||.|||.:|:|::..::..:||..
  Fly   396 EQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQ 460

Human   495 QADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQ 541
            ||.||...|.||..:||..:.| |.|::.::.    ..|.||..||:
  Fly   461 QAQLEAEIENLSWKIERAETTD-LGDLENQMD----IAEKRRTTLLK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARIH1	NP_005735.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		15/93 (16%)
		UBA-like. /evidence=ECO:0000305|PubMed:23707686	105..153		12/48 (25%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	182..393		92/211 (44%)
		RING-HC_RBR_HHARI	185..242	CDD:319540	20/56 (36%)
		IBR	257..317	CDD:214763	22/60 (37%)
		IBR	<339..379	CDD:396187	27/39 (69%)
		Ariadne domain. /evidence=ECO:0000305|PubMed:23707686	408..557		47/135 (35%)
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	19/53 (36%)
		IBR	222..284	CDD:214763	22/61 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930