DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GALE and Gale

DIOPT Version :9

Sequence 1:	NP_000394.2	Gene:	GALE / 2582	HGNCID:	4116	Length:	348	Species:	Homo sapiens
Sequence 2:	NP_001246537.1	Gene:	Gale / 38076	FlyBaseID:	FBgn0035147	Length:	350	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	208/345 - (60%)
Similarity:	263/345 - (76%)	Gaps:	2/345 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILD 69
            |||||||||||||||||:|.|||..:.:||..||:..|..|||:|.||||:||:.|.|..:||.|
  Fly     6 VLVTGGAGYIGSHTVLEMLNAGYNVICVDNLCNAYSSGAKLPEALSRVQEITGKKVNFYRVDITD 70

Human    70 QGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSAT 134
            :..::.:|:::....|.|||.|||||||.:.||.||..|:|||..|||.|..:.|...|:|||||
  Fly    71 REQVRSVFQEHKIDMVAHFAALKAVGESCRIPLQYYHNNMTGTNVLLEAMADNNVFKFVYSSSAT 135

Human   135 VYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGE 199
            |||.|::||:.|.||||.||:||||:|:|.||:::|||::||.|..|.||||||.|||.||.|||
  Fly   136 VYGEPKFLPVTEEHPTGNCTSPYGKTKYFTEEILKDLCKSDKRWAVVSLRYFNPVGAHISGRIGE 200

Human   200 DPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKE--QC 262
            ||.|.|||||||::|||:|||.:|:|:|:|:.|.||||||||||:||||:||:.||.||:.  :.
  Fly   201 DPNGEPNNLMPYIAQVAVGRRPSLSVYGSDFPTHDGTGVRDYIHIVDLAEGHVKALDKLRNIAET 265

Human   263 GCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLD 327
            |...||||||.|||||.||:|.|||||||:.|.:|.||.||||.|||:.:||.::|||.|..|:|
  Fly   266 GFFAYNLGTGVGYSVLDMVKAFEKASGKKVNYTLVDRRSGDVATCYADATLADKKLGWKAERGID 330

Human   328 RMCEDLWRWQKQNPSGFGTQ 347
            :||||.||||.|||:|:..:
  Fly   331 KMCEDTWRWQSQNPNGYANK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GALE	NP_000394.2	UDP_G4E_1_SDR_e	4..338	CDD:187558	203/334 (61%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:10801319, ECO:0000269\|PubMed:11279032, ECO:0000269\|PubMed:11279193, ECO:0000303\|PubMed:15175331	132..134		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:11279032, ECO:0000269\|PubMed:11279193	185..187		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:10801319, ECO:0000269\|PubMed:11279032, ECO:0000269\|PubMed:11279193	206..208		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:10801319, ECO:0000269\|PubMed:11279032, ECO:0000269\|PubMed:11279193	224..226		0/1 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:11279032, ECO:0000269\|PubMed:11279193	300..303		1/2 (50%)
Gale	NP_001246537.1	UDP_G4E_1_SDR_e	5..341	CDD:187558	203/334 (61%)
Gale	NP_001246537.1	galE	6..343	CDD:273487	204/336 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I654
eggNOG	1	0.900	-	-		E1_COG1087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H347
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1665
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54544
OrthoDB	1	1.010	-	-		D386435at33208
OrthoFinder	1	1.000	-	-		FOG0001696
OrthoInspector	1	1.000	-	-		oto88661
orthoMCL	1	0.900	-	-		OOG6_100506
Panther	1	1.100	-	-	LDO	PTHR43725
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1246
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840