DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLK5 and CG11313

DIOPT Version :10

Sequence 1:NP_036559.1 Gene:KLK5 / 25818 HGNCID:6366 Length:293 Species:Homo sapiens
Sequence 2:NP_651821.3 Gene:CG11313 / 43646 FlyBaseID:FBgn0039798 Length:370 Species:Drosophila melanogaster


Alignment Length:391 Identity:93/391 - (23%)
Similarity:144/391 - (36%) Gaps:131/391 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     9 MWVLCALITALLLGVTEHVLANNDVSCDHPS---------------NTVPSGSNQDLGAGAGEDA 58
            |.|:.|::..||:..|.|   ...|||.:|:               |:|.:.||           
  Fly     1 MKVIAAVLLCLLIIRTAH---GQYVSCRNPNQRTGYCVNIPLCVPLNSVLAKSN----------- 51

Human    59 RSDDSSSRIINGSDC-----------------DMHT---QP------------------------ 79
             ..||..|.|..|.|                 |.:|   :|                        
  Fly    52 -PTDSEMRFIRESRCLVSDQSDLPFVCCTPDTDYNTTRARPNDEVIHSTLLPDRSICGGDIAYNQ 115

Human    80 -------------WQAALLLRPN-----QLYCGAVLVHPQWLLTAAHCRKKVFR----------- 115
                         |...|..||:     :.||...|::.::::|||||.....|           
  Fly   116 ITKGNETVLTEFAWMVLLEYRPHDGQQLRTYCAGSLINNRYVVTAAHCVSAATRARKGDVSFRVS 180

Human   116 VRLGHYSLSPVYE--SGQQMFQGVKSIP-----HPGYSHPGHSNDLMLIKLNRRIRPTKDVRPIN 173
            ||||.::.|.|.:  :|:.:.:.|:...     |..:......||:.||:|.|.:..:..:||:.
  Fly   181 VRLGEHNTSAVVDCLNGRCLPEPVQIAVEEIRIHESFGTRLFWNDIALIRLAREVAYSPSIRPVC 245

Human   174 VSSHCP----SAGTKCLVSGWGTT----KSPQVHFPKVLQCLNISVLSQKRCEDAYPR--QIDDT 228
            :.|...    .:|....|:|||.|    .||      |...|.::.:....|...|..  .:.|:
  Fly   246 LPSTVGLQNWQSGQAFTVAGWGRTLTSESSP------VKMKLRVTYVEPGLCRRKYASIVVLGDS 304

Human   229 MFCAGDKAGRDSCQGDSGGPVVCNGS----LQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETI 289
            ..||..::..|||.||||||::....    |.|:||:| ..|.....|.||||:..:..||.:.|
  Fly   305 HLCAEGRSRGDSCDGDSGGPLMAFHEGVWVLGGIVSFG-LNCGSRFWPAVYTNVLSYETWITQNI 368

Human   290 Q 290
            :
  Fly   369 R 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLK5NP_036559.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68 8/45 (18%)
Tryp_SPc 66..285 CDD:214473 73/312 (23%)
CG11313NP_651821.3 CLIP 24..78 CDD:463440 12/65 (18%)
Tryp_SPc 116..367 CDD:238113 68/257 (26%)

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