Protein Alignment KLK5 and SPE

DIOPT Version :10

• Sequence 1: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Sequence 2: NP_651168.1
• Gene: SPE / 42791
• FlyBaseID: FBgn0039102
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 91/347 - (26%)
• Similarity: 146/347 - (42%)
• Gaps: 89/347 - (25%)

Human    15 LITALLLGVTEHV--LANNDVSCDHPS------NTVPSGSNQD-LGAG---AGEDARSDDSSSRI 67
            |::....|:...|  |.|..:.|...|      ::.|:.|.:| |..|   .|.|......:.||
  Fly    71 LLSKSQCGLDNRVEGLVNRILVCCPQSMRGNIMDSEPTPSTRDALQQGDVLPGNDVCGFLFADRI 135

Human    68 INGSDCDMHTQPWQAALLLRPNQLY-------CGAVLVHPQWLLTAAHCRKK---------VFRV 116
            ..|::..:...||.  :||:..:|:       ||..|::.:::|||.||...         :..|
  Fly   136 FGGTNTTLWEFPWM--VLLQYKKLFSETYTFNCGGALLNSRYVLTAGHCLASRELDKSGAVLHSV 198

Human   117 RLGHYSLSPVYESGQQM------------FQGVKSIPHPGYSHPG---HSNDLMLIKLNRRIRPT 166
            |||.:......:...||            .:..|.|.|..|: |.   ..||:.|::|.|.:..|
  Fly   199 RLGEWDTRTDPDCTTQMNGQRICAPKHIDIEVEKGIIHEMYA-PNSVDQRNDIALVRLKRIVSYT 262

Human   167 KDVRPINVSSHCPSAGTKCL----------------VSGWGTTKSPQVHFPKVLQC-LNISVLSQ 214
            ..||||            ||                |:|||.|::.|   |..::. :.::|.:.
  Fly   263 DYVRPI------------CLPTDGLVQNNFVDYGMDVAGWGLTENMQ---PSAIKLKITVNVWNL 312

Human   215 KRCEDAYPR---QIDDTMFCAGDKAGRDSCQGDSGGPV---VCNGS-----LQGLVSWGDYPCAR 268
            ..|::.|..   ::||:..|||.:.|.|:|.||||||:   :..|.     :.|:.|:|..||..
  Fly   313 TSCQEKYSSFKVKLDDSQMCAGGQLGVDTCGGDSGGPLMVPISTGGRDVFYIAGVTSYGTKPCGL 377

Human   269 PNRPGVYTNLCKFTKWIQETIQ 290
            ...|||||....|..||::.::
  Fly   378 KGWPGVYTRTGAFIDWIKQKLE 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		9/40 (23%)
		Tryp_SPc	66..285	CDD:214473	75/277 (27%)
SPE	NP_651168.1	CLIP	36..94	CDD:463440	5/22 (23%)
		Tryp_SPc	135..397	CDD:238113	76/279 (27%)