DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLK5 and CG7432

DIOPT Version :10

Sequence 1:NP_036559.1 Gene:KLK5 / 25818 HGNCID:6366 Length:293 Species:Homo sapiens
Sequence 2:NP_650825.2 Gene:CG7432 / 42347 FlyBaseID:FBgn0038727 Length:721 Species:Drosophila melanogaster


Alignment Length:266 Identity:78/266 - (29%)
Similarity:124/266 - (46%) Gaps:46/266 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    56 EDARSDDSSSRIINGSDCDMHTQPWQAALLL---RPNQLYCGAVLVHPQWLLTAAHCRK------ 111
            |..:.:.|:.||:.|.:......||.||:.|   :..:.:||..|:..:::||||||.:      
  Fly   464 ECGQQEYSTGRIVGGVEAPNGQWPWMAAIFLHGPKRTEFWCGGSLIGTKYILTAAHCTRDSRQKP 528

Human   112 ---KVFRVRLGHYSLSPVYESGQQMFQGVKSI-PHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPI 172
               :.|.||||...||...|....:...||.: .|..:|..|..||:.::.|::.:|.:|.|.|:
  Fly   529 FAARQFTVRLGDIDLSTDAEPSDPVTFAVKEVRTHERFSRIGFYNDIAILVLDKPVRKSKYVIPV 593

Human   173 NV--------SSHCPSAGTKCLVSGWGT--------TKSPQVHFPKVLQCLNISVLSQKRCEDAY 221
            .:        ....|  |.:..|.||||        |...|...|         :...:.|:.:|
  Fly   594 CLPKGIRMPPKERLP--GRRATVVGWGTTYYGGKESTSQRQAELP---------IWRNEDCDRSY 647

Human   222 PRQIDDTMFCAG-DKAGRDSCQGDSGGPVVCNGSLQ----GLVSWGDYPCARPNRPGVYTNLCKF 281
            .:.|::...||| ...|.|:||||||||::......    |:||:|: .|..|..|||||.:.::
  Fly   648 FQPINENFICAGYSDGGVDACQGDSGGPLMMRYDSHWVQLGVVSFGN-KCGEPGYPGVYTRVTEY 711

Human   282 TKWIQE 287
            ..||::
  Fly   712 LDWIRD 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLK5NP_036559.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68 3/11 (27%)
Tryp_SPc 66..285 CDD:214473 74/252 (29%)
CG7432NP_650825.2 CLIP 335..378 CDD:197829
Tryp_SPc 475..718 CDD:238113 75/255 (29%)
Blue background indicates that the domain is not in the aligned region.

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