Protein Alignment KLK5 and Sp7

DIOPT Version :10

• Sequence 1: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Sequence 2: NP_649734.2
• Gene: Sp7 / 40918
• FlyBaseID: FBgn0037515
• Length: 391
• Species: Drosophila melanogaster
• Alignment Length: 298
• Identity: 87/298 - (29%)
• Similarity: 136/298 - (45%)
• Gaps: 54/298 - (18%)

Human    38 PSNTVPSGSNQDLGAGAGEDARSDDS------SSRIINGSDCDMHTQPWQAALLLRPN----QLY 92
            |:.|..|...||..||.|....|...      |:::.||:|..:....|.|.|....|    :|.
  Fly   102 PTTTSSSSRGQDGQAGLGNLLPSPPKCGPHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELS 166

Human    93 CGAVLVHPQWLLTAAHC--------RKKVFRVRLGHYSLS------------PVYESGQQMFQGV 137
            ||..|::.:::||||||        ...:..||||.|..|            |:.:.|.:
  Fly   167 CGGSLINNRYVLTAAHCVIGAVETEVGHLTTVRLGEYDTSKDVDCIDDICNQPILQLGIE----- 226

Human   138 KSIPHPGYSHPGHSN---DLMLIKLNRRIRPTKDVRPI---NVSSHCP-SAGTKCLVSGWGTTKS 195
            ::..||.|. |.:.|   |:.|::|:|.:...:.::|:   .||:... :.|...:|||||.|.:
  Fly   227 QATVHPQYD-PANKNRIHDIALLRLDRPVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTTT 290

Human   196 PQVHFPKVLQCLNISVLSQKRCEDAYPRQ---IDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQ- 256
            .:.  ..:.|.|::.|.....|...:..:   :..:..|.|.:..||||.||||||::..|..|
  Fly   291 ARK--STIKQRLDLPVNDHDYCARKFATRNIHLISSQLCVGGEFYRDSCDGDSGGPLMRRGFDQA 353

Human   257 ----GLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQ 290
                |:||:|: .|.....|||||.:..:..||.|||:
  Fly   354 WYQEGVVSFGN-RCGLEGWPGVYTRVADYMDWIVETIR 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		10/35 (29%)
		Tryp_SPc	66..285	CDD:214473	72/257 (28%)
Sp7	NP_649734.2	CLIP	31..84	CDD:463440
		Tryp_SPc	137..388	CDD:238113	74/259 (29%)