DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLK5 and CG11529

DIOPT Version :10

Sequence 1:NP_036559.1 Gene:KLK5 / 25818 HGNCID:6366 Length:293 Species:Homo sapiens
Sequence 2:NP_648558.1 Gene:CG11529 / 39395 FlyBaseID:FBgn0036264 Length:287 Species:Drosophila melanogaster


Alignment Length:225 Identity:65/225 - (28%)
Similarity:102/225 - (45%) Gaps:21/225 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    79 PWQAALL---LRPNQLYCGAVLVHPQWLLTAAHCRKKV--FRVRLGHYSLSPVYESGQQMFQGVK 138
            |:|..|:   |...::.||..|:..:|:|||.||...|  :.|.||..|:.....||..:.:..|
  Fly    42 PYQVMLIGKQLWRKRILCGGTLLDKRWILTAGHCTMGVTHYDVYLGTKSVEDTEVSGGLVLRSNK 106

Human   139 SIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSS---HCPSAGTKCLVSGWGT----TKSP 196
            .|.|..::....:||:.|:||.:.:..|..::|.::.|   |...||...:.||||.    |.|.
  Fly   107 FIVHERFNPETAANDIALVKLPQDVAFTPRIQPASLPSRYRHDQFAGMSVVASGWGAMVEMTNSD 171

Human   197 QVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGS--LQGLV 259
            .      :|...:.|:|...|...|. .:...:.||........|.||||||:|...:  :.|:.
  Fly   172 S------MQYTELKVISNAECAQEYD-VVTSGVICAKGLKDETVCTGDSGGPLVLKDTQIVVGIT 229

Human   260 SWGDYPCARPNRPGVYTNLCKFTKWIQETI 289
            |:|.......|.||.:|.:..:..||:..|
  Fly   230 SFGPADGCETNIPGGFTRVTHYLDWIESKI 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLK5NP_036559.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68
Tryp_SPc 66..285 CDD:214473 62/219 (28%)
CG11529NP_648558.1 Tryp_SPc 37..258 CDD:238113 64/222 (29%)
Blue background indicates that the domain is not in the aligned region.

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