Protein Alignment KLK5 and thetaTry

DIOPT Version :10

• Sequence 1: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Sequence 2: NP_523693.1
• Gene: thetaTry / 36218
• FlyBaseID: FBgn0011555
• Length: 262
• Species: Drosophila melanogaster
• Alignment Length: 245
• Identity: 84/245 - (34%)
• Similarity: 135/245 - (55%)
• Gaps: 29/245 - (11%)

Human    62 DSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHC---RK--KVFRVRLGHY 121
            :...||:.|.|..:...|:|.:|..:....:||..|::...::|||||   ||  ||| ||||
  Fly    30 EREGRIVGGEDTTIGAHPYQVSLQTKSGSHFCGGSLINEDTVVTAAHCLVGRKVSKVF-VRLG-- 91

Human   122 SLSPVYESGQQMFQGVKSIPH-PGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKC 185
              |.:|..| .:...|:.:.: ..|:......|:.::||:.:::.|:::|.|.:::..|..||..
  Fly    92 --STLYNEG-GIVVAVRELAYNEDYNSKTMEYDVGILKLDEKVKETENIRYIELATETPPTGTTA 153

Human   186 LVSGWGTTKSPQVHF-----PKVLQCLNISVLSQKRC---EDAYPRQIDDTMFCAGDKAGRDSCQ 242
            :|:|||:    :.:|     ||.||.:.::::..|.|   |..|...|.|:|.||.:|. :|:||
  Fly   154 VVTGWGS----KCYFWCMTLPKTLQEVYVNIVDWKTCASDEYKYGEIIYDSMVCAYEKK-KDACQ 213

Human   243 GDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWI---QETI 289
            ||||||:....:|.|:|||| |.||....||||:::....|||   .||:
  Fly   214 GDSGGPLAVGNTLVGIVSWG-YACASNLLPGVYSDVPALRKWILNASETL 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		1/5 (20%)
		Tryp_SPc	66..285	CDD:214473	80/232 (34%)
thetaTry	NP_523693.1	Tryp_SPc	34..255	CDD:214473	80/232 (34%)