Protein Alignment KLK5 and Hayan

DIOPT Version :10

• Sequence 1: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Sequence 2: NP_001097020.1
• Gene: Hayan / 32831
• FlyBaseID: FBgn0030925
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 84/311 - (27%)
• Similarity: 128/311 - (41%)
• Gaps: 63/311 - (20%)

Human    31 NDVSCD----------HPSNTVPSGSN-----------QDLGAGAGEDARSDDS--SSRIINGSD 72
            ||||.:          :|:.|.|:..|           :.....|.|..||...  :..|::|..
  Fly   326 NDVSNNLDADPAPSIFNPAETRPTTPNPNPSRVNLPEKERPSVAACEKIRSGGKPLTVHILDGER 390

Human    73 CDMHTQPWQAALLLR---PNQLYCGAVLVHPQWLLTAAHC-----RKKVFRVRLGHYSLSPVYES 129
            .|....|..||:...   .....||..|:..:::||||||     ....| ||||..::    |:
  Fly   391 VDRGVYPHMAAIAYNSFGSAAFRCGGSLIASRFVLTAAHCVNSDDSTPSF-VRLGALNI----EN 450

Human   130 GQQMFQGVKSIP---HPGYSHPGHSNDLMLIKLNRRIRPTKDVRP--INVSSHCPSAGTKCLVSG 189
            .:..:|.:..|.   ||.||......|:.:::|....:.:..:||  :......|.|..|..|:|
  Fly   451 PEPGYQDINVIDVQIHPDYSGSSKYYDIAILQLAEDAKESDVIRPACLYTDRSDPPANYKYFVAG 515

Human   190 WGTTKSPQVHFPKVL-----------QCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGR-DSCQ 242
            ||..........|:|           :| |.|...|........|.:..:..||.||..| |:||
  Fly   516 WGVMNVTNRAVSKILLRAALDLVPADEC-NASFAEQPSANRTLRRGVIASQLCAADKNQRKDACQ 579

Human   243 GDSGGPVV-----CNG--SLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQ 286
            ||||||::     .:|  |:.|::|.| :.|| ...||:||.:..|..:|:
  Fly   580 GDSGGPLILEIDDVDGTYSIVGVISSG-FGCA-TKTPGLYTRVSSFLDYIE 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		8/43 (19%)
		Tryp_SPc	66..285	CDD:214473	71/250 (28%)
Hayan	NP_001097020.1	CLIP	32..80	CDD:197829
		Tryp_SPc	385..630	CDD:238113	72/252 (29%)