DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLK5 and Sp212

DIOPT Version :10

Sequence 1:NP_036559.1 Gene:KLK5 / 25818 HGNCID:6366 Length:293 Species:Homo sapiens
Sequence 2:NP_996209.2 Gene:Sp212 / 2768666 FlyBaseID:FBgn0053329 Length:516 Species:Drosophila melanogaster


Alignment Length:256 Identity:65/256 - (25%)
Similarity:115/256 - (44%) Gaps:32/256 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    59 RSDDSSSRIINGSDCDMHTQPWQAALL---LRPNQLYCGAVLVHPQWLLTAAHCRKKVFR----V 116
            |...::..|:.|::......||.:|:.   :|.....|...|:....:::||||..::..    |
  Fly   269 REGSTTPFIVRGNEFPRGQYPWLSAVYHKEVRALAFKCRGSLISSSIVISAAHCVHRMTEDRVVV 333

Human   117 RLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSN-DLMLIKLNRRIRPTKDVRPINVSSHC-- 178
            .||.|.|....|.|.:|...::.:.||.|:...:|: |:.||.:.|.:.....:.||     |  
  Fly   334 GLGRYDLDDYGEDGAEMRNVMRLLWHPDYNTRSYSDADIALITIERPVTFNDIIAPI-----CMW 393

Human   179 -----PSAGTKCLVSGWGTTK-SPQVHFPKVLQCLNISVLSQKRCEDAY-PRQIDDTMFCAGDKA 236
                 .:..|...::|||..: |.:..:|:|::.   .:.|...|...: ...:.:...|||::.
  Fly   394 TVEASRTVSTTGFIAGWGRDEDSSRTQYPRVVEA---EIASPTVCASTWRGTMVTERSLCAGNRD 455

Human   237 GRDSCQGDSGGPVVCNGS----LQGLVSWGDYPCA---RPNRPGVYTNLCKFTKWIQETIQ 290
            |...|.|||||.::....    |:|:||.|:...|   :.|:..:|.:|.|...||.|.|:
  Fly   456 GSGPCVGDSGGGLMVKQGDRWLLRGIVSAGERGPAGTCQLNQYVLYCDLSKHINWISENIR 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLK5NP_036559.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68 1/8 (13%)
Tryp_SPc 66..285 CDD:214473 60/242 (25%)
Sp212NP_996209.2 GD_N 23..127 CDD:464985
Tryp_SPc 277..514 CDD:238113 62/244 (25%)
Blue background indicates that the domain is not in the aligned region.

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