DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATXN10 and CG4975

DIOPT Version :9

Sequence 1:	NP_037368.1	Gene:	ATXN10 / 25814	HGNCID:	10549	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_001137693.2	Gene:	CG4975 / 37016	FlyBaseID:	FBgn0034266	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	98/428 - (22%)
Similarity:	165/428 - (38%)	Gaps:	97/428 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    93 IECSVNQNSIRNLDTIGVAV-DLILLFRELRVEQESL-----------LTAF------------R 133
            :..|:.:|.    :.|...: :|.||..:.|..||:|           ..||            .
  Fly    16 VRLSITENE----EEISALLKNLRLLLTKGRENQETLAESAEFSSFLNAVAFSPVMRTEHRLIHN 76

Human   134 CGLQFLGNIASRNEDSQSIVW----VHAFPELFLSCLNHPDKKI--VAYSSMI----LFTSLNHE 188
            ..||.|.|....||.:|:::|    :....:.:.|.|...:..:  :.|:..|    |.|.|  .
  Fly    77 LSLQVLANSVVNNETTQALIWSQHGLKIAEQAYASPLGSSNNVLLMIMYNIYISGHGLITDL--V 139

Human   189 RMK---ELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLM 250
            .:|   :|...||.|       |.....|:....:....:::.....|.:.||..::||..||.:
  Fly   140 ALKTCLQLWRALNEA-------QCTYNFEYLHFFLEHFIVQNGRACVACYQKLETEDRVAFLDYV 197

Human   251 IAKITSDEPLTKDDIPVF-LRHAELIASTF--VDQC--KTVLKLASEEPPDDEEALATIRLLDVL 310
            ...:..:.|  ..|:.:| |:|   .|..|  ...|  :..:||..|..|.:...     ||.::
  Fly   198 AHYLRENSP--NGDVTLFLLQH---FAKEFRMKSDCLLRETIKLKHELHPREVHT-----LLRII 252

Human   311 CEMTVNTELLGYLQVFP---GLLERVIDLLRVIHVAGKE------------------TTNIFSNC 354
            ...:.:.:   |..|:|   .|...|..|||.|..||||                  |::|.:
  Fly   253 ASASGSEK---YANVYPNDQSLFINVSSLLRCIVSAGKEPDGGGLDKPMTKLEEVALTSDIDA-- 312

Human   355 GCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVI 419
                  |....|:...|:.|:|...||.|.||.|:....:...:|.:|:...:...||.:.:|.|
  Fly   313 ------GYEKKVSYELKTLLVRCSANLLYDNKANKGYCLDTQLLPTLLECTTMDARNPLMREWSI 371

Human   420 YAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEV 457
            .||||...:..:.|.:||.:..||.|...:|.::..::
  Fly   372 LAIRNACINCPEAQQVIAGLTMQGSAPNDILTELNLDM 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN10	NP_037368.1	Atx10homo_assoc	370..467	CDD:286802	26/88 (30%)
CG4975	NP_001137693.2	Atx10homo_assoc	322..408	CDD:286802	26/85 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11993
eggNOG	1	0.900	-	-		E1_KOG2676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I5402
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005736
OrthoInspector	1	1.000	-	-		oto89760
orthoMCL	1	0.900	-	-		OOG6_104233
Panther	1	1.100	-	-	LDO	PTHR13255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R770
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.850