DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A6 and Zip71B

DIOPT Version :9

Sequence 1:	NP_036451.4	Gene:	SLC39A6 / 25800	HGNCID:	18607	Length:	755	Species:	Homo sapiens
Sequence 2:	NP_001097608.1	Gene:	Zip71B / 39626	FlyBaseID:	FBgn0036461	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	185/735 - (25%)
Similarity:	289/735 - (39%)	Gaps:	241/735 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    56 HLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEH 120
            ::.|:|.:||...:::.||...|:.::.:.:|:           .|..|..|..|...:.:...|
  Fly    31 YVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQ-----------FDPSHTIDQHRPQGYSNEMPH 84

Human   121 EHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSAS 185
            ..:..:.......:|...:.....:.|                           |.|..:|.|.:
  Fly    85 ATNVTYYFEPTRVNATDEEALELQISP---------------------------RGNHSNSQSEA 122

Human   186 EVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKG 250
            ||.              |.:|...|....|::.|......::.||.:|.:...      ::..|.
  Fly   123 EVP--------------EFLEIHDPKHRHPRESSEPVAACLSPKSLLSLIVNH------NDLHKN 167

Human   251 FMYSR--------------NTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDAR 301
            ..|.:              |:.|...|..|:            |.:....|..||||::.|||..
  Fly   168 IAYRKLLIKNDVSSTDGVHNSEEEYNEFINS------------VRITPRAFMKLCPALLAQIDNG 220

Human   302 SCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAV 366
            .|. ..:.:...:..|...:..||:...|.:.|:|...|||::|||||....::.:|.|||::||
  Fly   221 VCK-QPAVRSVNLNDKNQKIWYAWIYASITMLILSACGLLGILLVPLMKSAAYQEILKFLVSIAV 284

Human   367 GTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGL 431
            |||:|||.:|||||   :......|||....:  .||.|.....|  |:|..    .|.|.|..|
  Fly   285 GTLAGDALMHLLPH---ALFKEEKHEEEVTGI--NPLESDHKHSN--EAALL----CGCTFLAAL 338

Human   432 YFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRA 496
             ||:::|:::.|:|..|
  Fly   339 -FMYMLENLIPLLKGGK------------------------------------------------ 354

Human   497 DSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDY 561
                |.|                .|:|.                |.|.|   |:|
  Fly   355 ----PGH----------------GHSHG----------------HGHSH---GRS---------- 370

Human   562 HHILHHHHHQNHHPHSHSQRYSR----------------------EELKDAGVATLAWMVIMGDG 604
                          |.|.::.:.                      |:..|..:..:|:|||:|||
  Fly   371 --------------HGHMEKPAAKDAIDLPPPRELNVMLQEAKLDEKTPDRPLTPVAFMVIIGDG 421

Human   605 LHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAY 669
            |||.:|||||||||.....:|.:|:.||.||||||||||||:||:.|:::::||..|.:|::|::
  Fly   422 LHNLTDGLAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSF 486

Human   670 LGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEM--LHN--DASD-HGCSRWGYFFLQN 729
            :||:.|:||....:.::.||:|.|||.|:|:|..|:||.|  .||  .|.| .|      ..:|.
  Fly   487 VGMSVGLFIAGIGDGMTQWIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKG------IIIQI 545

Human   730 AGMLLGFGIMLLISIFEHKI 749
            .|:|||..|||.|::.||.:
  Fly   546 FGILLGGLIMLAIALNEHDL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A6	NP_036451.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..186		11/90 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..246		8/43 (19%)
		Zip	323..742	CDD:308248	136/445 (31%)
Zip71B	NP_001097608.1	Zip	242..559	CDD:280666	136/445 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10579
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.910